HitPredict

Interactor 1: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Interactor 2: JDP2 (Q8WYK2)
Jun dimerization protein 2
Gene: JDP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	22989952
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0006338 - chromatin remodeling and 1 others more... GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1084 Hs			1 163
+	Hs
		547761 HDAC4_HUMAN (1-1072): 0: 974: 100.00		ATF2_HUMAN (6-148): 1.25e-21: 92.2: 21.68
+	Hs
		579186 HDAC4_HUMAN (1-1072): 0: 974: 100.00		ATF3_HUMAN (3-162): 1.97e-20: 84.5: 45.61
+	Hs
		1264526 HDAC5_HUMAN (1-1084): 0: 785: 55.67		JDP2_HUMAN (1-163): 8.09e-33: 116: 100.00
+	Hs
		579236 HDAC5_HUMAN (1-1084): 0: 785: 55.67		ATF3_HUMAN (3-162): 1.97e-20: 84.5: 45.61
+	Hs
		1038579 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		JDP2_HUMAN (1-163): 8.09e-33: 116: 100.00
+	Mm
		140255 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		JDP2_MOUSE (1-163): 9.02e-33: 115: 96.32
+	Mm
		936382 HDAC2_MOUSE (647-1082): 2.51e-160: 485: 20.97		JDP2_MOUSE (1-163): 9.02e-33: 115: 96.32
+	Mm
		140216 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		JUNB_MOUSE (7-135): 5.35e-24: 97.2: 23.13
+	Dm
		599218 HDAC1_DROME (646-1081): 7.01e-160: 485: 20.75		FOSLA_DROME (18-159): 2.54e-25: 102: 27.27
+	Mm
		450547 HDAC2_MOUSE (647-1082): 2.51e-160: 485: 20.97		JUNB_MOUSE (7-135): 5.35e-24: 97.2: 23.13
+	Hs
		548245 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		FOSL1_HUMAN (29-162): 3.92e-21: 88.4: 32.84
+	Mm
		936396 HDAC2_MOUSE (647-1082): 2.51e-160: 485: 20.97		ATF3_MOUSE (3-162): 2.41e-24: 94.9: 44.44
+	Hs
		345504 HDAC2_HUMAN (647-1082): 7.5e-161: 486: 20.97		FOS_HUMAN (19-163): 1.76e-21: 91.1: 31.14
+	Hs
		579204 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		ATF3_HUMAN (3-162): 1.97e-20: 84.5: 45.61
+	Sp
		857023 CLR3_SCHPO (601-1050): 1.09e-150: 467: 33.62		ATF1_SCHPO (2-151): 1.51e-25: 103: 19.48
+	Mm
		526735 HDAC2_MOUSE (647-1082): 2.51e-160: 485: 20.97		FOSB_MOUSE (82-150): 5.11e-19: 83.7: 40.58
+	Sp
		223487 CLR6_SCHPO (651-1069): 1.36e-150: 456: 21.10		ATF1_SCHPO (2-151): 1.51e-25: 103: 19.48
+	Hs
		1264524 HDA10_HUMAN (654-1038): 2.39e-140: 439: 37.21		JDP2_HUMAN (1-163): 8.09e-33: 116: 100.00
+	Hs
		177189 HDAC3_HUMAN (651-1083): 8.19e-150: 455: 20.62		ATF3_HUMAN (3-162): 1.97e-20: 84.5: 45.61
+	Hs
		579223 HDA10_HUMAN (654-1038): 2.39e-140: 439: 37.21		ATF3_HUMAN (3-162): 1.97e-20: 84.5: 45.61