HitPredict

Interactor 1: HDAC4 (P56524)
Histone deacetylase 4 (HD4) (EC 3.5.1.98)
Gene: HDAC4

Interactor 2: NACC1 (Q96RE7)
Nucleus accumbens-associated protein 1 (NAC-1) (BTB/POZ domain-containing protein 14B)
Gene: NACC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	28319066, 16033423
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0008284 - positive regulation of cell population proliferation and 1 others more... GO:0042826 - histone deacetylase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1084 Hs			1 527
+	Hs
		781333 HDAC4_HUMAN (1-1072): 0: 974: 100.00		BCL6_HUMAN (6-350): 2.1e-49: 182: 19.07
+	Hs
		880692 HDAC4_HUMAN (1-1072): 0: 974: 100.00		ZBT16_HUMAN (4-346): 1.57e-48: 180: 20.52
+	Hs
		169703 HDAC4_HUMAN (1-1072): 0: 974: 100.00		ZBT7B_HUMAN (2-354): 3.46e-44: 165: 17.30
+	Hs
		880726 HDAC4_HUMAN (1-1072): 0: 974: 100.00		HIC1_HUMAN (7-293): 1.5e-42: 163: 20.40
+	Hs
		781479 HDAC9_HUMAN (25-1025): 0: 797: 56.25		BCL6_HUMAN (6-350): 2.1e-49: 182: 19.07
+	Hs
		781485 HDAC5_HUMAN (1-1084): 0: 785: 55.67		BCL6_HUMAN (6-350): 2.1e-49: 182: 19.07
+	Hs
		984041 HDAC5_HUMAN (1-1084): 0: 785: 55.67		ZBT16_HUMAN (4-346): 1.57e-48: 180: 20.52
+	Hs
		169735 HDAC5_HUMAN (1-1084): 0: 785: 55.67		ZBT7B_HUMAN (2-354): 3.46e-44: 165: 17.30
+	Hs
		781402 HDAC7_HUMAN (57-1084): 0: 679: 46.36		BCL6_HUMAN (6-350): 2.1e-49: 182: 19.07
+	Hs
		984001 HDAC7_HUMAN (57-1084): 0: 679: 46.36		ZBT16_HUMAN (4-346): 1.57e-48: 180: 20.52
+	Hs
		312063 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		ZBT7A_HUMAN (1-431): 6.26e-61: 212: 16.86
+	Mm
		140211 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		ZBT7A_MOUSE (1-404): 3.56e-59: 207: 15.82
+	Hs
		200286 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		ZBT43_HUMAN (2-360): 1.52e-55: 195: 23.86
+	Mm
		140266 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		Q3UQ17_MOUSE (4-346): 6.72e-53: 192: 20.81
+	Hs
		166167 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		ZBTB5_HUMAN (7-332): 3.13e-50: 184: 18.73
+	Hs
		781362 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		BCL6_HUMAN (6-350): 2.1e-49: 182: 19.07
+	Mm
		140282 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		ZBT7B_MOUSE (2-354): 9.29e-45: 167: 18.98
+	Mm
		140251 HDAC1_MOUSE (646-1080): 3.14e-163: 492: 21.46		BACH1_MOUSE (2-367): 1.62e-42: 163: 18.83
+	Hs
		157201 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		BACH1_HUMAN (4-263): 1.21e-38: 152: 20.53
+	Hs
		317598 HDAC1_HUMAN (646-1080): 2.95e-163: 492: 21.68		ZBT11_HUMAN (10-114): 5.03e-12: 70.9: 38.18