HitPredict

Interactor 1: SOX10 (P56693)
Transcription factor SOX-10
Gene: SOX10

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010628 - positive regulation of gene expression GO:0090090 - negative regulation of canonical Wnt signaling pathway GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 466 Hs			1 770
+	Hs
		980642 SOX7_HUMAN (84-451): 9.46e-42: 154: 26.12		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		727732 SOX5_HUMAN (96-180): 2.91e-37: 147: 47.06		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		818792 SOX9_HUMAN (13-466): 9.14e-38: 146: 47.14		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980649 SOX17_HUMAN (67-337): 3.55e-38: 145: 27.31		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		225730 SOX15_HUMAN (102-263): 1.84e-35: 133: 38.32		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980847 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		980859 SOX7_HUMAN (84-451): 9.46e-42: 154: 26.12		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		225731 SOX15_HUMAN (102-263): 1.84e-35: 133: 38.32		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Dm
		558384 PANG2_DROME (72-448): 1.75e-55: 201: 14.29		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Dm
		558368 PANG1_DROME (12-448): 1.47e-46: 173: 13.93		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Dm
		558392 CIC_DROME (103-450): 1.3e-41: 160: 14.25		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Dm
		558375 DICH_DROME (101-207): 1.8e-40: 151: 48.60		GROU_DROME (1-770): 7.74e-141: 433: 59.79
+	Hs
		727734 SOX5_HUMAN (96-180): 2.91e-37: 147: 47.06		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		993604 SOX17_HUMAN (67-337): 3.55e-38: 145: 27.31		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		225733 SOX15_HUMAN (102-263): 1.84e-35: 133: 38.32		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Hs
		245585 SOX10_HUMAN (1-466): 2.37e-71: 235: 100.00		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		245569 SOX5_HUMAN (96-180): 2.91e-37: 147: 47.06		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		245636 SOX17_HUMAN (67-337): 3.55e-38: 145: 27.31		TBL1X_HUMAN (569-769): 5.32e-46: 175: 16.51
+	Hs
		903450 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37
+	Hs
		903155 SRY_HUMAN (93-252): 9.95e-38: 138: 30.06		WDR5_HUMAN (655-769): 2.57e-36: 141: 21.37