HitPredict

Interactor 1: SOX10 (P56693)
Transcription factor SOX-10
Gene: SOX10

Interactor 2: LMO3 (Q8TAP4)
LIM domain only protein 3 (LMO-3) (Neuronal-specific transcription factor DAT1) (Rhombotin-3)
Gene: LMO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 466 Hs			1 145
+	Hs
		1301002 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		LHX6_HUMAN (3-137): 8.85e-42: 143: 36.30
+	Hs
		638236 SOX5_HUMAN (96-180): 2.91e-37: 147: 47.06		RBTN2_HUMAN (13-133): 8.21e-46: 148: 60.33
+	Hs
		1148474 PB1_HUMAN (1-338): 2.72e-32: 133: 12.72		LHX8_HUMAN (12-132): 3.05e-46: 155: 39.67
+	Hs
		1199217 PB1_HUMAN (1-338): 2.72e-32: 133: 12.72		LHX6_HUMAN (3-137): 8.85e-42: 143: 36.30
+	Ce
		590589 EGL13_CAEEL (16-187): 1.61e-34: 136: 31.79		HM14_CAEEL (3-141): 2.25e-40: 139: 28.37
+	Hs
		638483 SOX5_HUMAN (96-180): 2.91e-37: 147: 47.06		RBTN1_HUMAN (1-133): 5.2e-37: 125: 95.49
+	Hs
		1199163 PB1_HUMAN (1-338): 2.72e-32: 133: 12.72		LMO3_HUMAN (1-145): 3.61e-37: 125: 100.00
+	Hs
		1293388 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		PDLI5_HUMAN (3-66): 1.65e-12: 65.4: 27.69
+	Hs
		1281169 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		LHX4_HUMAN (72-144): 4.55e-12: 63.8: 19.18
+	Hs
		1300973 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		LHX3_HUMAN (4-68): 2.41e-11: 61.9: 21.21
+	Hs
		238117 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		LMX1B_HUMAN (4-70): 5.05e-11: 60.8: 26.47
+	Hs
		839810 CIC_HUMAN (34-358): 1.95e-43: 166: 19.10		LHX2_HUMAN (12-78): 7.86e-10: 57.7: 23.53
+	Dm
		1098042 DICH_DROME (101-207): 1.8e-40: 151: 48.60		Q9V472_DROME (72-144): 2.17e-11: 61.9: 21.92
+	Hs
		727819 SOX5_HUMAN (96-180): 2.91e-37: 147: 47.06		LHX3_HUMAN (4-68): 2.41e-11: 61.9: 21.21
+	Hs
		1199179 PB1_HUMAN (1-338): 2.72e-32: 133: 12.72		LHX4_HUMAN (72-144): 4.55e-12: 63.8: 19.18
+	Hs
		1199211 PB1_HUMAN (1-338): 2.72e-32: 133: 12.72		LHX3_HUMAN (4-68): 2.41e-11: 61.9: 21.21
+	Hs
		822645 PB1_HUMAN (1-338): 2.72e-32: 133: 12.72		LHX1_HUMAN (4-67): 3.28e-11: 61.5: 26.15
+	Hs
		839772 PB1_HUMAN (1-338): 2.72e-32: 133: 12.72		LHX2_HUMAN (12-78): 7.86e-10: 57.7: 23.53
+	Hs
		474066 UBFL1_HUMAN (32-325): 1.33e-30: 124: 11.36		LHX9_HUMAN (77-143): 1.21e-10: 60: 25.00
+	Hs
		474047 UBFL1_HUMAN (32-325): 1.33e-30: 124: 11.36		LHX2_HUMAN (12-78): 7.86e-10: 57.7: 23.53