HitPredict

Interactor 1: WNT7B (P56706)
Protein Wnt-7b
Gene: WNT7B

Interactor 2: WLS (Q5T9L3)
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)
Gene: WLS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22784633
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	MIG-14_Wnt-bd~wnt
Common GO terms	GO:0005886 - plasma membrane GO:0016055 - Wnt signaling pathway GO:0030666 - endocytic vesicle membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 349 Hs			1 541
+	Hs
		135861 WNT7A_HUMAN (1-349): 4.47e-171: 481: 77.94		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		568285 WNT3_MOUSE (12-349): 1.72e-158: 449: 44.25		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		881881 WNT4_HUMAN (3-349): 3.81e-156: 443: 48.57		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		881860 WNT3A_HUMAN (19-349): 4.24e-155: 440: 44.75		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		611175 WNT5A_MOUSE (1-349): 2.18e-153: 437: 44.84		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		782089 WNT5A_HUMAN (1-349): 1.24e-153: 438: 44.84		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135438 WNT5B_HUMAN (27-349): 5.08e-152: 433: 48.64		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		451998 WNT2_HUMAN (32-349): 1.16e-144: 414: 47.98		WLS_HUMAN (1-541): 0: 811: 100.00
+	Mm
		382254 WNT1_MOUSE (44-348): 1.35e-140: 404: 41.23		WLS_MOUSE (1-541): 0: 812: 96.12
+	Hs
		384072 WNT1_HUMAN (44-348): 1.41e-140: 404: 41.23		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135451 WNT16_HUMAN (19-349): 7.99e-136: 392: 45.35		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		158076 WNT9B_HUMAN (23-349): 1.35e-126: 368: 35.76		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135437 WNT8A_HUMAN (61-348): 9.86e-125: 363: 39.53		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		158068 WNT9A_HUMAN (21-349): 7.38e-118: 346: 36.42		WLS_HUMAN (1-541): 0: 811: 100.00
+	Hs
		1135420 WNT8B_HUMAN (61-348): 2.03e-113: 335: 43.39		WLS_HUMAN (1-541): 0: 811: 100.00
+	Dm
		658764 WNT2_DROME (29-349): 5.37e-130: 377: 49.40		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		776060 WNT4_DROME (38-349): 9.97e-107: 324: 31.56		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		1279554 Q9VM25_DROME (33-348): 7.89e-100: 305: 32.28		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		658776 WNT5_DROME (25-175): 8.34e-54: 192: 35.10		WLS_DROME (1-535): 0: 642: 40.82
+	Dm
		452324 WNTG_DROME (248-348): 9.27e-39: 145: 44.55		WLS_DROME (1-535): 0: 642: 40.82