HitPredict

Interactor 1: BACE1 (P56817)
Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Gene: BACE1

Interactor 2: TMX1 (Q9H3N1)
Thioredoxin-related transmembrane protein 1 (Protein disulfide-isomerase TMX1) (EC 5.3.4.1) (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein)
Gene: TMX1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.50	0.521

Property	Details
Experiments	29932915, 20354142
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 280
+	Hs
		671767 BACE1_HUMAN (1-501): 0: 520: 100.00		PDIA3_HUMAN (147-256): 2.92e-14: 74.4: 12.61
+	Hs
		423190 BACE1_HUMAN (1-501): 0: 520: 100.00		PDIA1_HUMAN (66-256): 1.82e-10: 62.8: 10.68