Interactor 1: BACE1 (P56817)
Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
Gene: BACE1
Interactor 2: GGA1 (Q9UJY5)
ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)
Gene: GGA1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.89 | 0.60 | 0.733 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 15466887, 15117318, 15886016, 26053850, 14567678 |
| Identification Methods | fluorescent resonance energy transfer, pull down, x-ray crystallography, affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, association, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0005769 - early endosome GO:0005794 - Golgi apparatus GO:0005802 - trans-Golgi network GO:0010008 - endosome membrane GO:0016020 - membrane |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
