HitPredict

Interactor 1: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Interactor 2: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	11782456
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0007229 - integrin-mediated signaling pathway and 1 others more... GO:0015629 - actin cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 572
+	Hs
		882316 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		1054771 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1054767 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		TRIP6_HUMAN (63-571): 6e-66: 224: 32.82
+	Hs
		1080815 MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		823361 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Dm
		1182662 Q7KVE5_DROME (6-866): 1.34e-69: 248: 23.16		Q8INW7_DROME (36-571): 1.7e-54: 195: 16.58
+	Hs
		823395 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Dm
		60033 A4IJ58_DROME (3-866): 1.15e-59: 220: 22.84		Q9VIX2_DROME (36-571): 1.2e-56: 201: 16.58
+	Hs
		816236 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95
+	Dm
		60024 A4IJ58_DROME (3-866): 1.15e-59: 220: 22.84		Q2PDT4_DROME (36-571): 8.31e-55: 196: 16.58
+	Hs
		823516 MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Hs
		1080794 CASS4_HUMAN (4-865): 6.37e-38: 154: 19.91		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		1355078 MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		823423 DNMBP_HUMAN (7-559): 6.75e-29: 126: 15.27		PAXI_HUMAN (8-500): 3.72e-32: 132: 12.12
+	Ce
		136803 UNC89_CAEEL (64-345): 5.87e-13: 75.6: 13.42		Q3S1I9_CAEEL (401-572): 5.41e-47: 168: 28.00
+	Hs
		1044710 CASS4_HUMAN (4-865): 6.37e-38: 154: 19.91		FHL3_HUMAN (410-544): 1.63e-09: 61.2: 28.99
+	Hs
		257611 ANR17_HUMAN (67-718): 5.11e-09: 62.6: 9.52		FHL2_HUMAN (468-572): 2.68e-19: 90.1: 21.91
+	Hs
		1050839 MAGL2_HUMAN (51-714): 5.5e-09: 62.2: 9.15		FHL2_HUMAN (468-572): 2.68e-19: 90.1: 21.91
+	Hs
		1050732 TITIN_HUMAN (56-404): 7.26e-09: 62.1: 14.93		FHL2_HUMAN (468-572): 2.68e-19: 90.1: 21.91
+	Hs
		816266 TITIN_HUMAN (56-404): 7.26e-09: 62.1: 14.93		LIMS1_HUMAN (383-566): 1.09e-10: 65.1: 25.95