HitPredict

Interactor 1: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Interactor 2: MPRIP (Q6WCQ1)
Myosin phosphatase Rho-interacting protein (M-RIP) (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28007913
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 1025
+	Hs
		882559 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		TARA_HUMAN (231-985): 1.44e-51: 201: 35.57
+	Mm
		222828 ACK1_MOUSE (9-581): 1.34e-29: 128: 13.93		MPRIP_MOUSE (1-1024): 9.38e-118: 388: 88.01
+	Hs
		728456 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		MYH11_HUMAN (124-786): 1.25e-12: 74.7: 11.57
+	Hs
		149428 MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		255304 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		HIP1R_HUMAN (626-929): 1.25e-09: 64.5: 19.56
+	Hs
		724828 CASL_HUMAN (1-868): 1.02e-91: 309: 35.96		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		725073 MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		1068700 MACF1_HUMAN (505-867): 1.44e-74: 269: 13.79		PLEC_HUMAN (499-978): 3.1e-11: 70.1: 14.96
+	Hs
		724786 DYST_HUMAN (457-866): 1.71e-67: 248: 12.07		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		1153260 DNMBP_HUMAN (7-559): 6.75e-29: 126: 15.27		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		148240 SC31A_HUMAN (101-520): 1.46e-24: 112: 12.97		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		149173 CHAP1_HUMAN (74-473): 9.49e-21: 100: 15.99		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Hs
		110636 H3BPE1_HUMAN (480-867): 1.8e-35: 148: 13.10		MYH9_HUMAN (540-1015): 1.52e-17: 90.5: 9.66
+	Hs
		1285194 SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44		PKHA5_HUMAN (318-1019): 7.56e-36: 149: 13.24
+	Hs
		203234 SYNJ1_HUMAN (281-696): 4.9e-10: 65.7: 13.47		PKHA7_HUMAN (336-980): 5.04e-41: 166: 13.51
+	Hs
		149481 PCLO_HUMAN (49-739): 1.71e-12: 73.8: 9.65		CTRO_HUMAN (195-1019): 1.45e-35: 149: 11.42
+	Mm
		222875 ACK1_MOUSE (9-581): 1.34e-29: 128: 13.93		MYH9_MOUSE (542-1025): 4.68e-18: 92.5: 8.68
+	Mm
		222845 ACK1_MOUSE (9-581): 1.34e-29: 128: 13.93		MYH10_MOUSE (534-1014): 8.31e-16: 85.1: 9.18
+	Hs
		255346 SH3K1_HUMAN (7-294): 1.08e-16: 86.7: 16.44		HIP1R_HUMAN (626-929): 1.25e-09: 64.5: 19.56
+	Dm
		1099861 Q9VLS7_DROME (65-706): 2.75e-10: 66.5: 9.08		OSP_DROME (268-1024): 1.05e-09: 65.1: 11.28