HitPredict

Interactor 1: BCAR1 (P56945)
Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
Gene: BCAR1

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	10692442, 33961781, 22081014
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, cosedimentation in solution, ion exchange chromatography, molecular sieving, pull down, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CAS_C~RasGEF, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0030424 - axon
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 860
+	Hs
		275559 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		BCAR3_HUMAN (55-860): 0: 715: 39.09
+	Hs
		882528 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		SH23A_HUMAN (207-853): 0: 538: 33.03
+	Hs
		412110 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		FYN_HUMAN (82-423): 9e-64: 225: 10.99
+	Hs
		433301 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Rn
		1144044 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		FYN_RAT (82-423): 7.75e-64: 225: 10.99
+	Hs
		522874 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Rn
		1144372 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		SRC_RAT (20-425): 1.35e-61: 219: 13.21
+	Mm
		403441 BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67		SRC_MOUSE (20-425): 9.19e-63: 222: 13.68
+	Hs
		850730 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		BMX_HUMAN (15-393): 6.23e-54: 200: 12.64
+	Hs
		433668 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		442799 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		411655 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		802545 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Hs
		802811 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		CRKL_HUMAN (220-480): 2.1e-51: 184: 18.12
+	Mm
		639448 BCAR1_MOUSE (1-870): 1.73e-102: 339: 88.67		LYN_MOUSE (110-394): 1.53e-53: 196: 11.59
+	Rn
		1144370 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		CRK_RAT (209-512): 1.33e-53: 190: 16.06
+	Hs
		882224 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		GRB2_HUMAN (214-310): 1.18e-27: 113: 27.00
+	Hs
		209020 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		NCK2_HUMAN (98-309): 6.4e-23: 103: 18.72
+	Hs
		655289 BCAR1_HUMAN (1-870): 2.49e-107: 352: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58
+	Rn
		1144371 BCAR1_RAT (2-870): 4.08e-103: 343: 89.12		P85A_RAT (202-319): 4.98e-16: 84.6: 22.58