HitPredict

Interactor 1: FUS (P56959)
RNA-binding protein FUS (Protein pigpen)
Gene: FUS

Interactor 2: SRSF2 (Q62093)
Serine/arginine-rich splicing factor 2 (Protein PR264) (Putative myelin regulatory factor 1) (MRF-1) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Gene: SRSF2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	9774382
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 518 Mm			1 221
+	Hs
		726840 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24
+	Hs
		516620 RBP56_HUMAN (3-447): 8.79e-40: 154: 45.41		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		967197 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24
+	Mm
		1143306 HTSF1_MOUSE (156-365): 5.74e-36: 144: 13.33		SRSF2_MOUSE (1-221): 1.22e-43: 147: 100.00
+	Hs
		516383 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		963966 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		SRSF2_HUMAN (1-221): 1.22e-43: 147: 100.00
+	Hs
		1031411 RBP56_HUMAN (3-447): 8.79e-40: 154: 45.41		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Hs
		297862 SC24D_HUMAN (21-292): 6.88e-14: 76.6: 14.61		SF3B4_HUMAN (4-205): 1.41e-52: 176: 17.24
+	Hs
		516768 RBM8A_HUMAN (238-359): 1.45e-23: 99.2: 29.51		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Mm
		892749 Q8BQ46_MOUSE (3-447): 4.21e-38: 148: 45.41		CIRBP_MOUSE (11-173): 3.38e-25: 98.8: 34.15
+	Hs
		726795 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Mm
		857328 EWS_MOUSE (3-444): 1.93e-42: 162: 35.31		TIA1_MOUSE (7-184): 8.63e-17: 79.6: 11.67
+	Hs
		967500 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		PUF60_HUMAN (8-108): 1.34e-23: 100: 23.76
+	Hs
		516495 PABP4_HUMAN (274-372): 4.92e-13: 73.6: 22.22		PABP1_HUMAN (6-202): 1.69e-41: 150: 18.27
+	Hs
		1020249 PABP4_HUMAN (274-372): 4.92e-13: 73.6: 22.22		ELAV2_HUMAN (1-195): 6.01e-38: 136: 15.79
+	Hs
		680441 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		TIA1_HUMAN (9-184): 2.34e-16: 78.5: 10.67
+	Hs
		1031507 RBM8A_HUMAN (238-359): 1.45e-23: 99.2: 29.51		PABP4_HUMAN (5-191): 4.16e-25: 104: 13.37
+	Hs
		967171 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		ELAV3_HUMAN (115-195): 1.55e-11: 64.6: 11.11
+	Hs
		474021 PABP4_HUMAN (274-372): 4.92e-13: 73.6: 22.22		PAB4L_HUMAN (15-92): 1.09e-20: 90.5: 26.92
+	Hs
		1119141 PAP1L_HUMAN (280-372): 1.17e-13: 75.5: 23.66		PABP5_HUMAN (16-95): 2.11e-18: 84.4: 21.25