HitPredict

Interactor 1: FUS (P56959)
RNA-binding protein FUS (Protein pigpen)
Gene: FUS

Interactor 2: SRS10 (Q9R0U0)
Serine/arginine-rich splicing factor 10 (FUS-interacting serine-arginine-rich protein 1) (Neural-salient serine/arginine-rich protein) (Neural-specific SR protein) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: Srsf10

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	9774382
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0030425 - dendrite GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 518 Mm			1 262
+	Hs
		266927 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00
+	Mm
		882688 FUS_MOUSE (1-518): 5.08e-44: 164: 100.00		SRSF2_MOUSE (4-90): 1.89e-24: 99.3: 45.65
+	Hs
		727096 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46
+	Mm
		952207 Q8BQ46_MOUSE (3-447): 4.21e-38: 148: 45.41		SRSF3_MOUSE (1-95): 1.17e-25: 100: 35.79
+	Hs
		1031411 RBP56_HUMAN (3-447): 8.79e-40: 154: 45.41		PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37
+	Mm
		1143306 HTSF1_MOUSE (156-365): 5.74e-36: 144: 13.33		SRSF2_MOUSE (4-90): 1.89e-24: 99.3: 45.65
+	Hs
		516620 RBP56_HUMAN (3-447): 8.79e-40: 154: 45.41		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35
+	Hs
		726746 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Hs
		967515 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46
+	Hs
		726795 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37
+	Hs
		516383 FUS_HUMAN (1-518): 1.02e-35: 141: 84.82		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35
+	Hs
		951928 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Hs
		963966 EWS_HUMAN (3-444): 5.23e-30: 126: 34.13		SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65
+	Hs
		952195 RBM8A_HUMAN (238-359): 1.45e-23: 99.2: 29.51		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Hs
		266904 PABP1_HUMAN (269-372): 1.46e-11: 69: 21.15		SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00
+	Hs
		1031507 RBM8A_HUMAN (238-359): 1.45e-23: 99.2: 29.51		PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37
+	Hs
		516768 RBM8A_HUMAN (238-359): 1.45e-23: 99.2: 29.51		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35
+	Hs
		951977 SF3B4_HUMAN (258-386): 1.96e-17: 86.5: 20.14		SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79
+	Hs
		516495 PABP4_HUMAN (274-372): 4.92e-13: 73.6: 22.22		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35
+	Hs
		516339 PABP1_HUMAN (269-372): 1.46e-11: 69: 21.15		PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35