HitPredict

Interactor 1: DSCR6 (P57055)
Protein ripply3 (Down syndrome critical region protein 6)
Gene: RIPPLY3

Interactor 2: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 190 Hs			1 743
+	Hs
		883098 DSCR6_HUMAN (1-190): 8.5e-104: 298: 100.00		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		883095 DSCR6_HUMAN (1-190): 8.5e-104: 298: 100.00		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		883097 DSCR6_HUMAN (1-190): 8.5e-104: 298: 100.00		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Hs
		980695 RIPP2_HUMAN (39-122): 1.01e-40: 136: 38.37		TLE2_HUMAN (1-743): 0: 552: 100.00
+	Hs
		980681 RIPP1_HUMAN (39-112): 2.9e-32: 115: 38.16		TLE2_HUMAN (1-743): 0: 552: 100.00
+	Hs
		980940 RIPP2_HUMAN (39-122): 1.01e-40: 136: 38.37		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		980621 RIPP2_HUMAN (39-122): 1.01e-40: 136: 38.37		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		980929 RIPP1_HUMAN (39-112): 2.9e-32: 115: 38.16		TLE4_HUMAN (1-743): 3.3e-176: 525: 65.93
+	Hs
		980593 RIPP1_HUMAN (39-112): 2.9e-32: 115: 38.16		TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46
+	Hs
		980774 RIPP2_HUMAN (39-122): 1.01e-40: 136: 38.37		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Xl
		193804 BOWL_XENLA (30-119): 1.33e-35: 123: 29.90		TLE4_XENLA (1-743): 1.3e-164: 495: 65.28
+	Hs
		980738 RIPP1_HUMAN (39-112): 2.9e-32: 115: 38.16		TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91
+	Hs
		883099 DSCR6_HUMAN (1-190): 8.5e-104: 298: 100.00		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		1132993 RIPP2_HUMAN (39-122): 1.01e-40: 136: 38.37		Q5T3G3_HUMAN (1-223): 3.33e-115: 349: 60.00
+	Hs
		1127609 RIPP2_HUMAN (39-122): 1.01e-40: 136: 38.37		Q5JSZ1_HUMAN (1-188): 5.44e-109: 332: 64.46
+	Hs
		1000245 RIPP1_HUMAN (39-112): 2.9e-32: 115: 38.16		Q5T3G3_HUMAN (1-223): 3.33e-115: 349: 60.00
+	Hs
		1000243 RIPP1_HUMAN (39-112): 2.9e-32: 115: 38.16		Q5JSZ1_HUMAN (1-188): 5.44e-109: 332: 64.46
+	Hs
		993463 RIPP2_HUMAN (39-122): 1.01e-40: 136: 38.37		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89
+	Hs
		993402 RIPP1_HUMAN (39-112): 2.9e-32: 115: 38.16		TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89