HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: MTPN (P58546)
Myotrophin (Protein V-1)
Gene: MTPN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	35914814
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~Ank_2, Ank_2~Ank_4, Ank_2~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 832 Hs			1 118
+	Hs
		883487 RIPK4_HUMAN (1-832): 0: 726: 100.00		ANK2_HUMAN (1-87): 3.16e-30: 114: 31.03
+	Hs
		885828 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		MTPN_HUMAN (1-118): 5.13e-42: 135: 100.00
+	Hs
		883496 RIPK4_HUMAN (1-832): 0: 726: 100.00		ANK3_HUMAN (1-87): 1.91e-26: 104: 27.59
+	Hs
		965154 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ANK2_HUMAN (1-87): 3.16e-30: 114: 31.03
+	Hs
		1021462 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		ANK3_HUMAN (1-87): 1.91e-26: 104: 27.59
+	Hs
		1349604 ANR50_HUMAN (353-788): 9.53e-101: 343: 24.36		RAI14_HUMAN (2-99): 2.66e-26: 103: 27.72
+	Hs
		161473 ANR50_HUMAN (353-788): 9.53e-101: 343: 24.36		MYPT1_HUMAN (4-87): 2.11e-16: 75.5: 25.00
+	Hs
		862028 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		ANK2_HUMAN (1-87): 3.16e-30: 114: 31.03
+	Hs
		225123 ANK1_HUMAN (233-737): 6.25e-92: 319: 21.44		MYPT2_HUMAN (4-87): 6.52e-20: 85.3: 27.38
+	Hs
		167036 ANR50_HUMAN (353-788): 9.53e-101: 343: 24.36		ANR28_HUMAN (12-93): 8.44e-09: 53.5: 34.15
+	Hs
		862012 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		DAPK1_HUMAN (2-87): 6.05e-24: 96.8: 27.91
+	Hs
		225160 TNKS2_HUMAN (490-831): 4.65e-82: 287: 25.71		MYPT2_HUMAN (4-87): 6.52e-20: 85.3: 27.38
+	Hs
		1329533 TNKS2_HUMAN (490-831): 4.65e-82: 287: 25.71		TNKS2_HUMAN (39-117): 4.37e-16: 74.5: 23.46
+	Mm
		103608 ANK2_MOUSE (592-832): 1.3e-65: 241: 27.89		ANK3_MOUSE (1-87): 3.56e-25: 100: 26.44
+	Hs
		167014 TNKS2_HUMAN (490-831): 4.65e-82: 287: 25.71		ANR28_HUMAN (12-93): 8.44e-09: 53.5: 34.15
+	Hs
		225134 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		MYPT2_HUMAN (4-87): 6.52e-20: 85.3: 27.38
+	Hs
		166913 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		ANR28_HUMAN (12-93): 8.44e-09: 53.5: 34.15
+	Hs
		166969 ANR44_HUMAN (319-717): 2.89e-62: 229: 19.91		ANR28_HUMAN (12-93): 8.44e-09: 53.5: 34.15
+	Hs
		166919 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		ANR28_HUMAN (12-93): 8.44e-09: 53.5: 34.15