HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21931591
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 832 Hs			1 497
+	Hs
		957782 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		883506 RIPK4_HUMAN (1-832): 0: 726: 100.00		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		1036348 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		883505 RIPK4_HUMAN (1-832): 0: 726: 100.00		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		1036078 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		883555 RIPK4_HUMAN (1-832): 0: 726: 100.00		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		1206048 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		201782 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		957806 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		957698 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		XIAP_HUMAN (1-497): 0: 569: 100.00
+	Hs
		201791 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		1036381 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		1036265 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		BIRC2_HUMAN (3-497): 9.73e-82: 267: 23.31
+	Hs
		862070 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		MIB1_HUMAN (311-492): 5.04e-16: 83.1: 13.68
+	Hs
		201790 RIPK2_HUMAN (31-276): 6.59e-54: 197: 44.94		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Mm
		1193396 DAPK1_MOUSE (578-830): 6.86e-62: 229: 26.74		MIB1_MOUSE (311-494): 3.28e-16: 83.8: 14.67
+	Hs
		1305542 KDIS_HUMAN (251-655): 7.94e-53: 202: 18.63		CGRF1_HUMAN (317-491): 2.2e-23: 102: 14.29
+	Hs
		1036246 RIPK3_HUMAN (21-371): 4.07e-34: 139: 30.39		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		1035698 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		BIRC3_HUMAN (150-394): 2.89e-41: 158: 23.94
+	Hs
		1038292 RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31		RFFL_HUMAN (446-497): 3.49e-18: 88: 44.23