HitPredict

Interactor 1: SHAN1 (D3YZU1)
SH3 and multiple ankyrin repeat domains protein 1 (Shank1)
Gene: Shank1

Interactor 2: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	27507650, 28706196, 28671696, 36417873
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0017124 - SH3 domain binding GO:0045202 - synapse GO:0050804 - modulation of chemical synaptic transmission and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 2167 Mm			1 1340
+	Mm
		88380 D3YZU5_MOUSE (1-2167): 3.71e-158: 543: 99.59		SYGP1_MOUSE (1-1340): 0: 1075: 100.00
+	Hs
		556720 ANK1_HUMAN (169-1052): 5.26e-61: 235: 12.82		SYGP1_HUMAN (1-1340): 0: 1065: 98.59
+	Mm
		100033 SHAN2_MOUSE (1141-2167): 1.39e-47: 190: 17.34		SYGP1_MOUSE (1-1340): 0: 1075: 100.00
+	Mm
		100050 ANK2_MOUSE (129-366): 8.72e-46: 185: 26.47		SYGP1_MOUSE (1-1340): 0: 1075: 100.00
+	Hs
		965139 ANK2_HUMAN (129-366): 3.27e-47: 190: 26.47		SYGP1_HUMAN (1-1340): 0: 1065: 98.59
+	Hs
		1299738 SHAN3_HUMAN (1241-2164): 1.24e-37: 158: 16.83		SYGP1_HUMAN (1-1340): 0: 1065: 98.59
+	Mm
		99981 SHAN3_MOUSE (297-1845): 2.91e-16: 87.8: 11.13		SYGP1_MOUSE (1-1340): 0: 1075: 100.00
+	Hs
		1299772 RAI14_HUMAN (182-406): 4.84e-14: 80.1: 28.76		SYGP1_HUMAN (1-1340): 0: 1065: 98.59
+	Hs
		596415 AN36B_HUMAN (112-283): 2.81e-35: 150: 14.54		RASA1_HUMAN (184-715): 9.24e-130: 428: 23.82
+	Hs
		883552 RIPK4_HUMAN (272-498): 3.98e-35: 148: 19.21		IQGA3_HUMAN (214-734): 8.69e-110: 383: 13.64
+	Hs
		1201452 Q9H4D1_HUMAN (251-512): 8.33e-35: 147: 18.56		IQGA3_HUMAN (214-734): 8.69e-110: 383: 13.64
+	Hs
		1021395 ANK3_HUMAN (32-266): 1.23e-21: 105: 17.45		IQGA2_HUMAN (216-691): 7.87e-116: 400: 13.38
+	Hs
		809460 RAI14_HUMAN (182-406): 4.84e-14: 80.1: 28.76		IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97
+	Mm
		980215 SHAN3_MOUSE (297-1845): 2.91e-16: 87.8: 11.13		NF1_MOUSE (408-712): 3.83e-82: 300: 23.51