HitPredict

Interactor 1: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Interactor 2: MACF1 (Q9UPN3)
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)
Gene: MACF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	35914814
Identification Methods	two hybrid fragment pooling approach
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, EF-hand_7~Pkinase
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 832 Hs			1 7388
+	Hs
		1330882 Q9H4D1_HUMAN (1-832): 0: 697: 90.75		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		965174 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		MACF1_HUMAN (1-7388): 0: 2387: 100.00
+	Hs
		506803 ANK1_HUMAN (233-737): 6.25e-92: 319: 21.44		SPTB1_HUMAN (3013-4737): 1.1e-28: 131: 8.92
+	Hs
		556695 ANK1_HUMAN (233-737): 6.25e-92: 319: 21.44		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		164586 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		862027 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		521508 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		ACTN1_HUMAN (921-1398): 1.47e-10: 70.5: 9.07
+	Hs
		862037 DAPK1_HUMAN (513-831): 7.19e-83: 292: 25.16		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		513849 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		DMD_HUMAN (239-1700): 1.65e-14: 84.4: 8.22
+	Hs
		164604 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		963292 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		965102 ANK2_HUMAN (592-832): 1.31e-65: 241: 27.89		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Mm
		561172 ANK2_MOUSE (592-832): 1.3e-65: 241: 27.89		SPTN1_MOUSE (433-1344): 2.66e-09: 66.8: 14.03
+	Hs
		1021404 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		PLEC_HUMAN (2677-3656): 8.53e-27: 124: 8.13
+	Hs
		809198 KDIS_HUMAN (251-655): 7.94e-53: 202: 18.63		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		164611 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		SPTN2_HUMAN (3436-4815): 1.06e-11: 74.8: 9.59
+	Hs
		963306 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		SPTB2_HUMAN (6378-7134): 6.05e-11: 72.5: 13.80
+	Hs
		809108 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		UTRN_HUMAN (428-1437): 8.81e-11: 71.9: 13.98
+	Hs
		1021399 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		SPTN1_HUMAN (433-1344): 7.43e-10: 68.8: 13.39
+	Hs
		1021458 ANK3_HUMAN (659-832): 4.77e-45: 178: 32.57		SPTN4_HUMAN (4289-5023): 8.23e-09: 65.5: 19.24