HitPredict

Interactor 1: KLF3 (P57682)
Krueppel-like factor 3 (Basic krueppel-like factor) (CACCC-box-binding protein BKLF) (TEF-2)
Gene: KLF3

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35140242, 38297188
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 345 Hs			1 3969
+	Hs
		975354 KLF12_HUMAN (239-345): 1.44e-52: 180: 83.18		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		884265 KLF3_HUMAN (1-345): 4.46e-98: 295: 100.00		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		317029 KLF8_HUMAN (1-342): 9.85e-87: 267: 36.99		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		1357297 KLF12_HUMAN (239-345): 1.44e-52: 180: 83.18		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		203785 ZN436_HUMAN (84-344): 3.96e-106: 320: 20.07		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Hs
		1080129 ZN397_HUMAN (5-344): 1.43e-76: 246: 17.05		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		884244 KLF3_HUMAN (1-345): 4.46e-98: 295: 100.00		SUV92_HUMAN (3577-3969): 7.13e-82: 278: 18.97
+	Hs
		165654 KLF3_HUMAN (1-345): 4.46e-98: 295: 100.00		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		165608 KLF8_HUMAN (1-342): 9.85e-87: 267: 36.99		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		599072 ZNF10_HUMAN (67-312): 4.3e-45: 164: 13.95		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		203806 KLF15_HUMAN (258-342): 8.09e-30: 119: 63.53		SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97
+	Hs
		165744 KLF12_HUMAN (239-345): 1.44e-52: 180: 83.18		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		152621 KLF3_HUMAN (1-345): 4.46e-98: 295: 100.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		316970 KLF8_HUMAN (1-342): 9.85e-87: 267: 36.99		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18
+	Hs
		152569 KLF8_HUMAN (1-342): 9.85e-87: 267: 36.99		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		1046715 KLF5_HUMAN (217-342): 5.6e-39: 145: 63.36		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		152643 KLF5_HUMAN (217-342): 5.6e-39: 145: 63.36		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		204195 KLF4_HUMAN (223-342): 2.87e-35: 136: 60.00		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		152558 KLF4_HUMAN (223-342): 2.87e-35: 136: 60.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		152697 KLF15_HUMAN (258-342): 8.09e-30: 119: 63.53		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47