HitPredict

Interactor 1: TMPS3 (P57727)
Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein)
Gene: TMPRSS3

Interactor 2: LRIG3 (Q6UXM1)
Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)
Gene: LRIG3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_8~Trypsin
Common GO terms	-
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 1119
+	Hs
		1166665 TMPSD_HUMAN (53-449): 2.32e-113: 347: 37.04		LRIG3_HUMAN (2-1119): 0: 769: 100.00
+	Hs
		1166669 TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16		LRIG3_HUMAN (2-1119): 0: 769: 100.00
+	Hs
		1378220 TEST_HUMAN (207-451): 5.85e-99: 300: 38.37		ROBO1_HUMAN (501-1088): 1.46e-64: 242: 16.38
+	Hs
		1291092 ST14_HUMAN (72-449): 4.39e-108: 340: 29.23		LIGO1_HUMAN (311-786): 7.13e-32: 134: 17.66
+	Hs
		299592 TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16		LRIG2_HUMAN (773-1091): 2.37e-33: 141: 12.05
+	Hs
		299569 TM11B_HUMAN (43-449): 2.39e-107: 325: 27.49		LRIG2_HUMAN (773-1091): 2.37e-33: 141: 12.05
+	Hs
		177760 TMPS2_HUMAN (27-451): 6.62e-117: 353: 40.19		SLIT2_HUMAN (43-227): 2.01e-12: 73.9: 32.63
+	Hs
		428698 TRY1_HUMAN (207-452): 5.08e-94: 285: 34.27		LGR4_HUMAN (254-454): 4.7e-33: 140: 28.86
+	Hs
		1294957 TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16		LRIG1_HUMAN (1-187): 2.9e-16: 86.4: 14.98
+	Hs
		296681 ST14_HUMAN (72-449): 4.39e-108: 340: 29.23		SLIT2_HUMAN (43-227): 2.01e-12: 73.9: 32.63
+	Hs
		1198133 TM11B_HUMAN (43-449): 2.39e-107: 325: 27.49		LRIG1_HUMAN (1-187): 2.9e-16: 86.4: 14.98
+	Hs
		296677 TMPS4_HUMAN (76-452): 6.28e-110: 333: 33.16		SLIT2_HUMAN (43-227): 2.01e-12: 73.9: 32.63