HitPredict

Interactor 1: CLD2 (P57739)
Claudin-2 (SP82)
Gene: CLDN2

Interactor 2: ZO1 (Q07157)
Tight junction protein ZO-1 (Tight junction protein 1) (Zona occludens protein 1) (Zonula occludens protein 1)
Gene: TJP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10601346
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 230 Hs			1 1748
+	Hs
		881971 CLD8_HUMAN (1-230): 4.21e-90: 266: 32.47		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		315115 CLD7_HUMAN (1-210): 5.77e-88: 260: 36.02		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		881967 CLD6_HUMAN (1-214): 4.18e-81: 243: 38.43		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		325492 CLD1_HUMAN (1-210): 6.25e-81: 242: 35.55		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		131310 CLD5_HUMAN (1-208): 9.82e-80: 239: 34.76		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Hs
		146030 CLD4_HUMAN (1-192): 3.22e-79: 238: 40.10		ZO1_HUMAN (1-1748): 0: 925: 100.00
+	Mm
		761869 CLD8_MOUSE (1-230): 4.84e-88: 261: 32.04		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Mm
		192030 CLD4_MOUSE (1-210): 6.01e-86: 255: 39.05		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Mm
		291871 CLD1_MOUSE (1-210): 4.15e-86: 255: 35.07		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Mm
		291875 CLD2_MOUSE (1-230): 4.55e-84: 251: 91.30		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Mm
		761870 CLD7_MOUSE (1-210): 3.72e-83: 248: 36.97		ZO1_MOUSE (1-1748): 0: 874: 90.79
+	Hs
		303739 CLD1_HUMAN (1-210): 6.25e-81: 242: 35.55		ZO3_HUMAN (13-915): 5.56e-135: 446: 38.65
+	Mm
		291873 CLD1_MOUSE (1-210): 4.15e-86: 255: 35.07		ZO3_MOUSE (13-928): 3.15e-128: 427: 37.70
+	Mm
		291874 CLD1_MOUSE (1-210): 4.15e-86: 255: 35.07		ZO2_MOUSE (172-572): 2.71e-15: 84.2: 16.94
+	Hs
		325496 CLD1_HUMAN (1-210): 6.25e-81: 242: 35.55		INADL_HUMAN (60-583): 5.65e-19: 96.5: 18.77
+	Mm
		192031 CLD4_MOUSE (1-210): 6.01e-86: 255: 39.05		MPDZ_MOUSE (418-540): 2.31e-13: 78: 25.19
+	Mm
		291872 CLD1_MOUSE (1-210): 4.15e-86: 255: 35.07		MPDZ_MOUSE (418-540): 2.31e-13: 78: 25.19
+	Hs
		146034 CLD4_HUMAN (1-192): 3.22e-79: 238: 40.10		DLG1_HUMAN (263-512): 3.61e-17: 90: 16.54
+	Hs
		884690 CLD2_HUMAN (1-230): 1.08e-82: 247: 100.00		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98
+	Hs
		325501 CLD1_HUMAN (1-210): 6.25e-81: 242: 35.55		ZO2_HUMAN (391-610): 1e-09: 65.7: 17.98