HitPredict

Interactor 1: FBXW4 (P57775)
F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)
Gene: FBXW4

Interactor 2: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.88 1.00 0.943

The method score is based on:

Property Details
Experiments 27705803, 33961781, 22388891, 23658844, 20596027, 22632967
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0005829 - cytosol
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 412
Hs

1 163
+ Mm
+ Mm
+ Hs
+ Sp
+ Ce
+ Sp
+ Mm
+ Hs
+ Dm
+ Sp
+ Dm
+ Dm
+ Ce
+ Sp
+ Dm
+ Mm
+ Hs
+ Dm
+ Sc
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024