HitPredict

Interactor 1: FBXW4 (P57775)
F-box/WD repeat-containing protein 4 (Dactylin) (F-box and WD-40 domain-containing protein 4)
Gene: FBXW4

Interactor 2: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	29103612, 37028429, 25143387, 25515538, 14603323, 23658844
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0005829 - cytosol GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 412 Hs			1 776
+	Mm
		1337557 FBXW4_MOUSE (17-412): 1.41e-83: 263: 91.44		CUL1_MOUSE (1-776): 0: 912: 99.87
+	Hs
		1041266 FBW1B_HUMAN (34-411): 3.49e-81: 260: 16.03		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		903206 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Mm
		1257398 FBXW7_MOUSE (24-276): 6.01e-44: 164: 14.89		CUL1_MOUSE (1-776): 0: 912: 99.87
+	Hs
		1041133 FBXW7_HUMAN (24-276): 1.51e-43: 163: 14.89		CUL1_HUMAN (1-776): 0: 911: 100.00
+	Hs
		885039 FBXW4_HUMAN (21-412): 3.66e-83: 262: 98.22		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		1043297 FBW1B_HUMAN (34-411): 3.49e-81: 260: 16.03		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		1043637 FBW1B_HUMAN (34-411): 3.49e-81: 260: 16.03		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		792982 LIS1_HUMAN (7-322): 9.15e-67: 219: 13.20		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		903208 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		903209 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1043085 WDR5B_HUMAN (33-319): 2.7e-61: 203: 12.80		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		1043441 WDR5B_HUMAN (33-319): 2.7e-61: 203: 12.80		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Sp
		142915 POF1_SCHPO (69-411): 1.08e-70: 235: 19.19		CUL1_SCHPO (1-776): 0: 733: 40.92
+	Hs
		903207 WDR5_HUMAN (1-319): 1.97e-65: 213: 12.61		CUL3_HUMAN (9-776): 0: 748: 30.47
+	Sp
		142916 POP1_SCHPO (28-411): 1.3e-59: 208: 14.88		CUL1_SCHPO (1-776): 0: 733: 40.92
+	Hs
		1043499 FBXW7_HUMAN (24-276): 1.51e-43: 163: 14.89		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1043114 POC1B_HUMAN (238-411): 3.76e-36: 139: 10.92		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		1043469 POC1B_HUMAN (238-411): 3.76e-36: 139: 10.92		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1042101 POC1B_HUMAN (238-411): 3.76e-36: 139: 10.92		CUL3_HUMAN (9-776): 0: 748: 30.47