HitPredict

Interactor 1: SESN2 (P58004)
Sestrin-2 (EC 1.11.1.-) (Hypoxia-induced gene)
Gene: SESN2

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	25263562, 28199315, 35831510, 26972053
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0034198 - cellular response to amino acid starvation GO:1904262 - negative regulation of TORC1 signaling GO:1904263 - positive regulation of TORC1 signaling
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 974
+	Hs
		1162319 SESN1_HUMAN (22-480): 0: 774: 58.23		WDR59_HUMAN (1-974): 0: 805: 100.00
+	Hs
		885147 SESN3_HUMAN (29-480): 0: 770: 56.60		WDR59_HUMAN (1-974): 0: 805: 100.00
+	Hs
		885117 SESN2_HUMAN (1-480): 0: 873: 100.00		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Hs
		885138 SESN2_HUMAN (1-480): 0: 873: 100.00		WDR24_HUMAN (3-165): 3.25e-20: 98.7: 12.79
+	Hs
		1301642 SESN1_HUMAN (22-480): 0: 774: 58.23		WDR24_HUMAN (3-165): 3.25e-20: 98.7: 12.79
+	Hs
		885148 SESN3_HUMAN (29-480): 0: 770: 56.60		WDR24_HUMAN (3-165): 3.25e-20: 98.7: 12.79