HitPredict

Interactor 1: MPP2 (D3ZAA9)
MAGUK p55 subfamily member 2 (Protein MPP2)
Gene: MPP2

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PDZ~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0032590 - dendrite membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 552 Rn			1 1383
+	Ce
		873634 LIN2_CAEEL (5-552): 8.06e-143: 438: 33.17		INSR_CAEEL (31-1361): 0: 915: 29.55
+	Hs
		159179 CSKP_HUMAN (2-552): 6.34e-151: 458: 38.06		EPHA4_HUMAN (662-1328): 0: 570: 24.19
+	Hs
		159214 CSKP_HUMAN (2-552): 6.34e-151: 458: 38.06		EPHA7_HUMAN (664-1321): 0: 568: 22.55
+	Hs
		1072518 MPP7_HUMAN (1-552): 2.54e-146: 435: 35.11		EPHA7_HUMAN (664-1321): 0: 568: 22.55
+	Hs
		385630 PALS2_HUMAN (12-552): 0: 527: 68.51		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		159135 CSKP_HUMAN (2-552): 6.34e-151: 458: 38.06		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		1081505 MPP7_HUMAN (1-552): 2.54e-146: 435: 35.11		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		872433 DLG1_HUMAN (63-246): 6.27e-15: 80: 12.57		EPHA5_HUMAN (662-1320): 0: 581: 24.11
+	Hs
		872639 DLG1_HUMAN (63-246): 6.27e-15: 80: 12.57		EPHA4_HUMAN (662-1328): 0: 570: 24.19
+	Hs
		609417 PALS1_HUMAN (26-551): 4.11e-140: 422: 34.38		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		609253 EM55_HUMAN (94-552): 1.27e-135: 403: 38.88		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		338534 MPP7_HUMAN (1-552): 2.54e-146: 435: 35.11		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		338283 EM55_HUMAN (94-552): 1.27e-135: 403: 38.88		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		942352 DLG4_HUMAN (99-224): 4.37e-16: 83.4: 19.55		NTRK2_HUMAN (997-1293): 1.8e-67: 246: 42.72
+	Mm
		546303 DLG4_MOUSE (99-224): 4.41e-16: 83.4: 19.55		NTRK2_MOUSE (997-1293): 1.64e-66: 244: 42.38
+	Hs
		384746 DLG1_HUMAN (63-246): 6.27e-15: 80: 12.57		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		942346 DLG4_HUMAN (99-224): 4.37e-16: 83.4: 19.55		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		1070968 DLG2_HUMAN (131-366): 1.05e-15: 82.7: 13.04		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Mm
		1142638 DLG4_MOUSE (99-224): 4.41e-16: 83.4: 19.55		ERBB4_MOUSE (44-347): 9.25e-26: 117: 20.42
+	Hs
		383736 DLG4_HUMAN (99-224): 4.37e-16: 83.4: 19.55		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83