HitPredict

Interactor 1: SESN3 (P58005)
Sestrin-3 (EC 1.11.1.-)
Gene: SESN3

Interactor 2: WDR24 (Q96S15)
GATOR2 complex protein WDR24 (EC 2.3.2.27) (WD repeat-containing protein 24)
Gene: WDR24

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	25263562, 26449471
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016239 - positive regulation of macroautophagy GO:0034198 - cellular response to amino acid starvation GO:1904262 - negative regulation of TORC1 signaling
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 492 Hs			1 790
+	Hs
		1301642 SESN1_HUMAN (8-492): 0: 795: 61.84		WDR24_HUMAN (1-790): 0: 594: 100.00
+	Hs
		885138 SESN2_HUMAN (26-492): 0: 739: 56.93		WDR24_HUMAN (1-790): 0: 594: 100.00
+	Hs
		885147 SESN3_HUMAN (1-492): 0: 873: 100.00		WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31
+	Hs
		885150 SESN3_HUMAN (1-492): 0: 873: 100.00		MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22
+	Hs
		1162319 SESN1_HUMAN (8-492): 0: 795: 61.84		WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31
+	Hs
		1347918 SESN1_HUMAN (8-492): 0: 795: 61.84		MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22
+	Hs
		885130 SESN2_HUMAN (26-492): 0: 739: 56.93		WDR59_HUMAN (159-345): 6.31e-21: 100: 20.31
+	Hs
		885141 SESN2_HUMAN (26-492): 0: 739: 56.93		MIOS_HUMAN (2-326): 4.54e-17: 87.9: 13.22
+	Hs
		885117 SESN2_HUMAN (26-492): 0: 739: 56.93		WDR5_HUMAN (1-102): 2.39e-12: 71: 14.42