HitPredict

Interactor 1: D3ZIC4 (D3ZIC4)
Protein phosphatase 1 regulatory subunit
Gene: Ppp1r12b

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Ank_2~fn3, Ank_2~Recep_L_domain
Common GO terms	GO:0019901 - protein kinase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 993 Rn			1 1383
+	Hs
		665591 ANK3_HUMAN (27-332): 1.06e-56: 217: 22.38		EPHB2_HUMAN (662-1317): 0: 577: 23.01
+	Hs
		665280 MIB1_HUMAN (2-462): 4.73e-64: 236: 16.57		EPHA2_HUMAN (662-1321): 2.76e-167: 528: 22.70
+	Hs
		225124 MYPT2_HUMAN (1-983): 1.77e-162: 505: 86.34		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		665581 ANK2_HUMAN (6-143): 1.78e-23: 110: 22.45		EPHB2_HUMAN (662-1317): 0: 577: 23.01
+	Hs
		665490 ANS1B_HUMAN (224-903): 3.93e-21: 102: 12.23		EPHA8_HUMAN (663-1323): 1.14e-174: 548: 22.59
+	Hs
		385170 ANR44_HUMAN (7-361): 8.03e-75: 268: 19.68		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		609480 PP16A_HUMAN (1-379): 7.86e-84: 282: 32.14		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		166874 ANR28_HUMAN (1-309): 1.4e-66: 245: 18.93		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		385120 MIB1_HUMAN (2-462): 4.73e-64: 236: 16.57		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		1021409 ANK3_HUMAN (27-332): 1.06e-56: 217: 22.38		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		385487 TANC1_HUMAN (1-216): 6.69e-35: 147: 18.30		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		384666 ANK2_HUMAN (6-143): 1.78e-23: 110: 22.45		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		338353 ANK3_HUMAN (27-332): 1.06e-56: 217: 22.38		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		257545 ANR17_HUMAN (197-888): 3.34e-22: 106: 13.38		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Rn
		728451 KDIS_RAT (3-127): 3.41e-20: 99.1: 17.42		NTRK1_RAT (997-1287): 8.91e-65: 238: 41.28
+	Hs
		338292 ANK2_HUMAN (6-143): 1.78e-23: 110: 22.45		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		338632 ANS1B_HUMAN (224-903): 3.93e-21: 102: 12.23		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		339124 KDIS_HUMAN (3-127): 4.45e-20: 98.7: 17.42		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		1070979 ANS1B_HUMAN (224-903): 3.93e-21: 102: 12.23		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		383867 ANS1B_HUMAN (224-903): 3.93e-21: 102: 12.23		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83