HitPredict

Interactor 1: NALP5 (P59047)
NACHT, LRR and PYD domains-containing protein 5 (Mater protein homolog) (Maternal Antigen that Embryos Require)
Gene: NLRP5

Interactor 2: LRRC1 (Q9BTT6)
Leucine-rich repeat-containing protein 1 (LANO adapter protein) (LAP and no PDZ protein)
Gene: LRRC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LRR_1~LRR_6, LRR_6~LRR_8
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1200 Hs			1 524
+	At
		1338065 BRL2_ARATH (790-1188): 7.01e-48: 188: 18.48		RGI1_ARATH (3-459): 1.43e-61: 220: 23.09
+	At
		84605 RGI3_ARATH (478-932): 5.53e-40: 163: 12.45		RGI1_ARATH (3-459): 1.43e-61: 220: 23.09
+	At
		84594 RGI3_ARATH (478-932): 5.53e-40: 163: 12.45		ERL2_ARATH (5-302): 1.79e-48: 181: 26.30
+	Mm
		1246902 NLRP3_MOUSE (927-1190): 3.5e-44: 176: 35.85		FLII_MOUSE (5-207): 1.23e-34: 141: 28.02
+	At
		1338062 EMS1_ARATH (478-754): 2.47e-16: 86.7: 12.50		RGI1_ARATH (3-459): 1.43e-61: 220: 23.09
+	At
		84616 RGI3_ARATH (478-932): 5.53e-40: 163: 12.45		CLV1_ARATH (201-523): 2.1e-33: 137: 19.88
+	Hs
		1301451 NOD2_HUMAN (981-1195): 2.07e-19: 96.7: 19.44		ERBIN_HUMAN (176-523): 1.94e-52: 194: 23.71
+	At
		1352203 BRL2_ARATH (790-1188): 7.01e-48: 188: 18.48		Y1723_ARATH (284-521): 1.48e-20: 97.6: 13.57
+	At
		84509 BRL2_ARATH (790-1188): 7.01e-48: 188: 18.48		GSO1_ARATH (314-523): 5.45e-17: 86.5: 12.78
+	At
		84448 RGI3_ARATH (478-932): 5.53e-40: 163: 12.45		GSO1_ARATH (314-523): 5.45e-17: 86.5: 12.78
+	At
		1338953 BRL2_ARATH (790-1188): 7.01e-48: 188: 18.48		Y1571_ARATH (405-521): 7.11e-09: 60.7: 12.69
+	At
		84588 RGI3_ARATH (478-932): 5.53e-40: 163: 12.45		BAME1_ARATH (323-521): 6e-16: 83.4: 12.26
+	At
		84593 RGI3_ARATH (478-932): 5.53e-40: 163: 12.45		ERECT_ARATH (365-522): 6.78e-15: 79.9: 7.29
+	At
		1323635 GSO2_ARATH (497-803): 7.9e-24: 111: 11.43		EMS1_ARATH (234-523): 5.07e-27: 118: 21.33
+	At
		221776 GSO2_ARATH (497-803): 7.9e-24: 111: 11.43		BAME1_ARATH (323-521): 6e-16: 83.4: 12.26
+	At
		84461 SKM1_ARATH (600-912): 3.23e-22: 105: 10.95		GSO1_ARATH (314-523): 5.45e-17: 86.5: 12.78
+	At
		84451 Y4361_ARATH (513-779): 1.97e-20: 100: 9.30		GSO1_ARATH (314-523): 5.45e-17: 86.5: 12.78
+	At
		221796 EMS1_ARATH (478-754): 2.47e-16: 86.7: 12.50		BAME1_ARATH (323-521): 6e-16: 83.4: 12.26
+	At
		1114712 EMS1_ARATH (478-754): 2.47e-16: 86.7: 12.50		ERECT_ARATH (365-522): 6.78e-15: 79.9: 7.29