HitPredict

Interactor 1: D3ZPU3 (D3ZPU3)
Very-long-chain 3-oxoacyl-CoA reductase (EC 1.1.1.330) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (Estradiol 17-beta-dehydrogenase 12)
Gene: Hsd17b12

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 308 Rn			1 1383
+	Rn
		544849 Q5I0N4_RAT (54-249): 2.1e-10: 62.8: 24.04		INSR_RAT (1-1383): 0: 1575: 100.00
+	Hs
		435661 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		1121036 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		384950 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		1018331 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		MERTK_HUMAN (810-1302): 3.9e-61: 230: 31.54
+	Hs
		1081501 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		NTRK3_HUMAN (997-1291): 5.26e-62: 230: 38.80
+	Hs
		609330 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		384940 HSDL1_HUMAN (5-306): 4.51e-73: 229: 37.42		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		338515 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383841 DHB12_HUMAN (1-308): 5.87e-94: 282: 78.53		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Hs
		338368 DHRS2_HUMAN (48-298): 2.87e-68: 215: 21.09		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		338559 DRS7B_HUMAN (3-306): 9.67e-60: 195: 20.67		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		385176 DHB11_HUMAN (50-237): 5.8e-11: 63.9: 28.93		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		383657 DHB3_HUMAN (9-308): 8.51e-65: 207: 36.07		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83