HitPredict

Interactor 1: GBG2 (P59768)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)
Gene: GNG2

Interactor 2: GNAI1 (P63096)
Guanine nucleotide-binding protein G(i) subunit alpha-1 (Adenylate cyclase-inhibiting G alpha protein)
Gene: GNAI1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	22759790, 33961781
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0005886 - plasma membrane GO:0007186 - G protein-coupled receptor signaling pathway GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 71 Hs			1 354
+	Hs
		837675 GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47		GNAI1_HUMAN (1-354): 0: 512: 100.00
+	Hs
		444694 GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		391364 GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		444709 GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41		GNAI3_HUMAN (1-354): 1.51e-179: 503: 93.79
+	Hs
		391359 GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		391377 GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41		GNAI2_HUMAN (1-354): 3.51e-178: 499: 87.89
+	Hs
		450995 GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Hs
		451002 GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41		GNAO_HUMAN (1-354): 4.45e-175: 491: 72.11
+	Mm
		579644 GBG2_MOUSE (1-71): 3.57e-29: 100: 100.00		GNAO_MOUSE (1-354): 1.59e-172: 485: 71.83
+	Hs
		580465 GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41		GNAT2_HUMAN (1-354): 8.28e-172: 483: 69.49
+	Hs
		837595 GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		837590 GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47		GNAQ_HUMAN (1-353): 3.49e-167: 472: 52.26
+	Hs
		670442 GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00		GNA11_HUMAN (1-353): 1.33e-162: 460: 51.13
+	Hs
		670436 GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47		GNA11_HUMAN (1-353): 1.33e-162: 460: 51.13
+	Hs
		580416 GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		580419 GBG3_HUMAN (4-71): 3.14e-27: 95.1: 79.41		GNAZ_HUMAN (1-353): 2.73e-160: 454: 67.23
+	Hs
		887107 GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00		GNA13_HUMAN (2-353): 1.72e-155: 443: 39.17
+	Hs
		837678 GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47		GNA13_HUMAN (2-353): 1.72e-155: 443: 39.17
+	Hs
		887098 GBG2_HUMAN (1-71): 3.57e-29: 100: 100.00		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23
+	Hs
		837674 GBG4_HUMAN (1-71): 6.54e-28: 97: 77.47		GNAS2_HUMAN (1-354): 3.5e-143: 412: 38.23