HitPredict

Interactor 1: CD81 (P60033)
CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81)
Gene: CD81

Interactor 2: CD166 (Q13740)
CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
Gene: ALCAM

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	30024968, 32900848
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001772 - immunological synapse GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 236 Hs			1 583
+	Hs
		905511 TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67		CD166_HUMAN (1-583): 9.66e-116: 357: 100.00
+	Hs
		602254 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		CD166_HUMAN (1-583): 9.66e-116: 357: 100.00
+	Hs
		326065 TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48		CD166_HUMAN (1-583): 9.66e-116: 357: 100.00
+	Hs
		842252 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		BCAM_HUMAN (26-505): 5.31e-81: 268: 23.62
+	Hs
		842253 TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67		BCAM_HUMAN (26-505): 5.31e-81: 268: 23.62
+	Hs
		602234 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		BCAM_HUMAN (26-505): 5.31e-81: 268: 23.62
+	Hs
		842269 TSN14_HUMAN (11-230): 6.42e-52: 170: 21.65		BCAM_HUMAN (26-505): 5.31e-81: 268: 23.62
+	Hs
		793255 TSN5_HUMAN (7-235): 3.13e-55: 179: 21.67		MUC18_HUMAN (1-575): 2.5e-74: 251: 20.42
+	Hs
		602229 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		MUC18_HUMAN (1-575): 2.5e-74: 251: 20.42
+	Hs
		326044 TSN15_HUMAN (10-230): 9.93e-44: 150: 15.48		BCAM_HUMAN (26-505): 5.31e-81: 268: 23.62
+	Dm
		52381 Q7KJ73_DROME (3-234): 3.84e-44: 149: 21.37		A1Z7J1_DROME (91-506): 4.74e-46: 176: 17.84
+	Hs
		887951 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		CADM1_HUMAN (259-493): 5.61e-20: 94.9: 19.64
+	Hs
		887903 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		CADM4_HUMAN (252-575): 6.18e-20: 94.2: 19.67
+	Hs
		888000 CD81_HUMAN (1-236): 6.2e-63: 197: 100.00		ROBO1_HUMAN (385-580): 1.75e-17: 89: 11.54
+	Hs
		602297 CD9_HUMAN (1-234): 3.88e-53: 172: 43.59		ROBO1_HUMAN (385-580): 1.75e-17: 89: 11.54
+	Hs
		1199563 TSN33_HUMAN (9-233): 7.63e-51: 168: 22.78		TITIN_HUMAN (45-566): 6.99e-10: 64.7: 10.66