HitPredict

Interactor 1: EIF3E (P60228)
Eukaryotic translation initiation factor 3 subunit E (eIF3e) (Eukaryotic translation initiation factor 3 subunit 6) (Viral integration site protein INT-6 homolog) (eIF-3 p48)
Gene: EIF3E

Interactor 2: EIF3C (Q99613)
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 subunit 8) (eIF3 p110)
Gene: EIF3C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 24981860, 33961781, 35235311, 34349018, 17403899, 28514442, 23623729, 10504338
Identification Methods affinity chromatography technology, cross-linking study, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains eIF-3c_N~eIF3_N, PCI~eIF3_N, PCI~eIF-3c_N, PCI~PCI
Common GO terms GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005829 - cytosol
GO:0005852 - eukaryotic translation initiation factor 3 complex
and 5 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 445
Hs

1 913
+ Hs
+ Dm
+ At
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024