HitPredict

Interactor 1: D4A563 (D4A563)
Pseudopodium-enriched atypical kinase 1
Gene: Peak1

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~fn3, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0004672 - protein kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1733 Rn			1 1383
+	Hs
		435763 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Mm
		546263 AKT1_MOUSE (1348-1708): 1.42e-104: 345: 13.37		INSR_MOUSE (1-1383): 0: 1538: 97.83
+	Hs
		872489 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		EPHA5_HUMAN (662-1320): 0: 581: 24.11
+	Hs
		665659 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		EPHB2_HUMAN (662-1317): 0: 577: 23.01
+	Hs
		1072599 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		EPHA7_HUMAN (664-1321): 0: 568: 22.55
+	Hs
		665432 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		EPHA3_HUMAN (661-1320): 4.01e-172: 541: 24.15
+	Hs
		435552 AKT1_HUMAN (1314-1708): 3.72e-105: 347: 12.94		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		1332902 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		1083894 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		NTRK2_HUMAN (997-1293): 1.8e-67: 246: 42.72
+	Hs
		385530 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		338986 PEAK1_HUMAN (1-1733): 0: 1285: 85.87		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		665151 AKT1_HUMAN (1314-1708): 3.72e-105: 347: 12.94		EPHA2_HUMAN (662-1321): 2.76e-167: 528: 22.70
+	Hs
		568557 KAPCA_HUMAN (1332-1700): 6.41e-105: 341: 15.12		EPHA2_HUMAN (662-1321): 2.76e-167: 528: 22.70
+	Hs
		981066 KPCT_HUMAN (1263-1714): 4.92e-102: 346: 13.45		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		601822 AKT1_HUMAN (1314-1708): 3.72e-105: 347: 12.94		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		338005 AKT2_HUMAN (1339-1700): 1.88e-106: 350: 13.03		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		338004 AKT1_HUMAN (1314-1708): 3.72e-105: 347: 12.94		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		568539 KAPCA_HUMAN (1332-1700): 6.41e-105: 341: 15.12		ERBB3_HUMAN (5-368): 5.74e-31: 135: 19.70
+	Hs
		337895 KAPCA_HUMAN (1332-1700): 6.41e-105: 341: 15.12		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		383640 AKT1_HUMAN (1314-1708): 3.72e-105: 347: 12.94		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83