HitPredict

Interactor 1: PTEN (P60484)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (EC 3.1.3.-) (Mutated in multiple advanced cancers 1) (Phosphatase and tensin homolog)
Gene: PTEN

Interactor 2: UBP13 (Q92995)
Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13)
Gene: USP13

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	26453058, 33378983, 24270891, 26280536, 31200745
Identification Methods	affinity chromatography technology, pull down, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0050821 - protein stabilization
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 403 Hs			1 863
+	Hs
		890693 PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00		UBP39_HUMAN (93-708): 1.17e-81: 275: 13.77
+	Hs
		890879 PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00		UBP25_HUMAN (336-854): 7.03e-72: 258: 17.79
+	Hs
		890785 PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00		USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86
+	Mm
		139366 PTEN_MOUSE (1-403): 8.54e-168: 477: 99.75		USP9X_MOUSE (296-701): 3.7e-69: 252: 16.63
+	Hs
		777024 PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00		UBP8_HUMAN (686-861): 1.79e-20: 99.7: 12.64
+	Hs
		890641 PTEN_HUMAN (1-403): 4.63e-168: 478: 100.00		UBP4_HUMAN (460-606): 2.3e-11: 69.8: 16.34
+	Hs
		56548 PTPC1_HUMAN (26-161): 2.55e-25: 110: 23.38		USP9X_HUMAN (296-701): 3.34e-69: 252: 16.86