HitPredict

Interactor 1: PP4C (P60510)
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)
Gene: PPP4C

Interactor 2: PTPA (Q15257)
Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B')
Gene: PTPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 19156129
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Metallophos~PTPA
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 307 Hs			1 358
+	Hs
		915197 PP2AB_HUMAN (6-307): 0: 523: 65.23		PTPA_HUMAN (1-358): 0: 576: 100.00
+	Hs
		930855 PP2AA_HUMAN (6-307): 0: 522: 65.89		PTPA_HUMAN (1-358): 0: 576: 100.00
+	Hs
		905914 PP1A_HUMAN (2-304): 0: 517: 43.89		PTPA_HUMAN (1-358): 0: 576: 100.00
+	Mm
		885636 PP2AA_MOUSE (6-307): 0: 522: 65.89		PTPA_MOUSE (1-358): 0: 526: 86.87
+	Mm
		885635 PP1A_MOUSE (2-304): 0: 518: 44.20		PTPA_MOUSE (1-358): 0: 526: 86.87
+	At
		138693 PP2A5_ARATH (2-307): 0: 516: 65.03		Q9C5N3_ARATH (9-354): 2.74e-153: 438: 39.94
+	Dm
		284476 PP4C_DROME (1-307): 0: 523: 91.53		PTPA_DROME (27-358): 2.6e-144: 415: 43.68
+	Sc
		618806 PP2A1_YEAST (4-307): 1.5e-148: 423: 60.98		PTPA2_YEAST (24-357): 1.71e-131: 381: 34.02
+	Sc
		618780 PP2A1_YEAST (4-307): 1.5e-148: 423: 60.98		PTPA1_YEAST (53-348): 1.19e-117: 347: 40.00
+	Sc
		688125 PP4C_YEAST (6-307): 7.03e-149: 421: 63.07		PTPA1_YEAST (53-348): 1.19e-117: 347: 40.00