HitPredict

Interactor 1: PP4C (P60510)
Serine/threonine-protein phosphatase 4 catalytic subunit (PP4C) (Pp4) (EC 3.1.3.16) (Protein phosphatase X) (PP-X)
Gene: PPP4C

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	15364934, 24362026
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 307 Hs			1 833
+	Hs
		930942 PP2AA_HUMAN (6-307): 0: 522: 65.89		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		930913 PP2AA_HUMAN (6-307): 0: 522: 65.89		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Hs
		647866 PP2AB_HUMAN (6-307): 0: 523: 65.23		MARK3_HUMAN (14-595): 2.5e-139: 432: 17.20
+	Hs
		915261 PP2AB_HUMAN (6-307): 0: 523: 65.23		MARK4_HUMAN (14-608): 3.78e-137: 426: 17.54
+	Hs
		915182 PP2AB_HUMAN (6-307): 0: 523: 65.23		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		930835 PP2AA_HUMAN (6-307): 0: 522: 65.89		KCC2B_HUMAN (11-532): 3.27e-131: 408: 19.64
+	Hs
		681777 PP2AA_HUMAN (6-307): 0: 522: 65.89		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Mm
		682104 PP2AA_MOUSE (6-307): 0: 522: 65.89		AKT1_MOUSE (1-337): 5.84e-129: 396: 23.12
+	Hs
		682162 PP2AA_HUMAN (6-307): 0: 522: 65.89		AKT2_HUMAN (1-337): 6.85e-129: 396: 23.19
+	Hs
		931045 PP2AA_HUMAN (6-307): 0: 522: 65.89		AKT3_HUMAN (10-351): 5.23e-128: 394: 24.29
+	Ce
		108325 PP2A_CAEEL (2-307): 0: 523: 63.73		GCK1_CAEEL (12-448): 1.04e-118: 375: 31.77
+	Hs
		131559 PP4C_HUMAN (1-307): 0: 536: 100.00		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		131561 PP2AB_HUMAN (6-307): 0: 523: 65.23		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		131564 PP2AA_HUMAN (6-307): 0: 522: 65.89		STK25_HUMAN (10-367): 8.05e-117: 362: 36.21
+	Hs
		915296 PP2AB_HUMAN (6-307): 0: 523: 65.23		STK26_HUMAN (1-396): 1.9e-116: 361: 33.84
+	Hs
		915317 PP2AB_HUMAN (6-307): 0: 523: 65.23		STK24_HUMAN (9-295): 4.54e-116: 361: 42.36
+	Hs
		931026 PP2AA_HUMAN (6-307): 0: 522: 65.89		STK26_HUMAN (1-396): 1.9e-116: 361: 33.84
+	Hs
		931059 PP2AA_HUMAN (6-307): 0: 522: 65.89		STK24_HUMAN (9-295): 4.54e-116: 361: 42.36
+	Dm
		619891 PP2A_DROME (2-307): 0: 522: 64.05		HIPPO_DROME (13-289): 5.89e-110: 353: 43.17
+	Mm
		915321 PP2AB_MOUSE (6-307): 0: 523: 65.23		TNIK_MOUSE (11-296): 3.3e-64: 236: 42.57