HitPredict

Interactor 1: GBRL2 (P60520)
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABA(A) receptor-associated protein-like 2) (Ganglioside expression factor 2) (GEF-2) (General protein transport factor p16) (Golgi-associated ATPase enhancer of 16 kDa) (GATE-16) (MAP1 light chain 3-related protein)
Gene: GABARAPL2

Interactor 2: ATG4D (Q86TL0)
Cysteine protease ATG4D (EC 3.4.22.-) (AUT-like 4 cysteine endopeptidase) (Autophagy-related cysteine endopeptidase 4) (Autophagin-4) (Autophagy-related protein 4 homolog D) (HsAPG4D) [Cleaved into: Cysteine protease ATG4D, mitochondrial]
Gene: ATG4D

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19549685
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ATG8~Peptidase_C54
Common GO terms	GO:0000045 - autophagosome assembly GO:0005737 - cytoplasm GO:0006914 - autophagy GO:0015031 - protein transport
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 117 Hs			1 474
+	Hs
		306219 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4D_HUMAN (1-474): 0: 733: 100.00
+	Hs
		1198603 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4D_HUMAN (1-474): 0: 733: 100.00
+	Hs
		306269 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4C_HUMAN (60-474): 0: 531: 46.04
+	Hs
		1288559 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4C_HUMAN (60-474): 0: 531: 46.04
+	Hs
		891370 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66
+	Hs
		306368 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66
+	Hs
		1328075 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66
+	Mm
		1206409 MLP3A_MOUSE (5-117): 2.01e-45: 144: 41.74		ATG4B_MOUSE (93-474): 1.51e-156: 451: 30.66
+	Ce
		999365 LGG1_CAEEL (1-116): 2.15e-55: 170: 57.76		ATG42_CAEEL (54-460): 2.79e-142: 419: 31.83
+	Hs
		1330686 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		ATG4B_HUMAN (93-474): 3.2e-151: 437: 30.66
+	Hs
		891248 GBRL2_HUMAN (1-117): 1.08e-58: 178: 100.00		ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27
+	Hs
		306253 GBRAP_HUMAN (1-117): 7.55e-57: 173: 57.27		ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27
+	Hs
		1264549 GBRL1_HUMAN (1-116): 7.89e-56: 170: 61.21		ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27
+	Hs
		1264550 MLP3A_HUMAN (5-117): 2.01e-45: 144: 41.74		ATG4A_HUMAN (94-437): 1.39e-137: 403: 31.27
+	Dm
		1372164 Q9W2S2_DROME (1-117): 5.35e-58: 176: 57.27		Q9VPW2_DROME (90-455): 1.95e-123: 367: 32.26
+	Ce
		111920 LGG1_CAEEL (1-116): 2.15e-55: 170: 57.76		ATG41_CAEEL (86-474): 2.66e-122: 367: 23.84
+	Dm
		1179054 Q7K1J3_DROME (1-116): 4.36e-54: 168: 51.72		Q9VPW2_DROME (90-455): 1.95e-123: 367: 32.26
+	Dm
		114224 Q9VEG5_DROME (1-116): 4.49e-54: 166: 51.72		M9PBM3_DROME (90-455): 1.79e-123: 367: 32.26
+	Dm
		1364631 Q9VEG5_DROME (1-116): 4.49e-54: 166: 51.72		Q9VPW2_DROME (90-455): 1.95e-123: 367: 32.26
+	Sc
		746022 ATG8_YEAST (1-116): 1.06e-58: 178: 56.03		ATG4_YEAST (96-431): 1.74e-91: 288: 26.09