HitPredict

Interactor 1: UB2G2 (P60604)
Ubiquitin-conjugating enzyme E2 G2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme G2) (Ubiquitin carrier protein G2) (Ubiquitin-protein ligase G2)
Gene: UBE2G2

Interactor 2: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19269966
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005783 - endoplasmic reticulum GO:0006511 - ubiquitin-dependent protein catabolic process GO:0036503 - ERAD pathway GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 165 Hs			1 180
+	Hs
		1307272 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		RNF5_HUMAN (1-164): 8.79e-56: 175: 100.00
+	Hs
		919838 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		RNF5_HUMAN (1-164): 8.79e-56: 175: 100.00
+	Hs
		1292368 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	Hs
		919826 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		RN185_HUMAN (17-179): 7.02e-52: 166: 60.98
+	At
		715141 UBC9_ARATH (4-164): 8.38e-73: 217: 36.03		Q9LN67_ARATH (6-168): 4.25e-35: 124: 26.94
+	Hs
		919822 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		TRI11_HUMAN (14-148): 2.69e-31: 119: 17.78
+	Hs
		919712 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		TRI26_HUMAN (14-123): 1.73e-28: 112: 21.85
+	Hs
		1318532 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		1336390 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		919851 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		TRI31_HUMAN (19-126): 9.14e-27: 106: 20.91
+	Hs
		919870 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		TRI39_HUMAN (24-148): 5.72e-26: 104: 21.43
+	Hs
		919828 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		RN170_HUMAN (12-133): 1.15e-26: 103: 22.48
+	Hs
		1354526 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		TRI10_HUMAN (14-156): 5.89e-24: 99: 17.45
+	Hs
		584923 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		RO52_HUMAN (23-148): 9.12e-25: 101: 18.11
+	Mm
		919925 UB2D2_MOUSE (4-164): 5.65e-73: 217: 36.03		TRI17_MOUSE (13-148): 1.18e-24: 100: 13.10
+	Hs
		919892 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		TRI10_HUMAN (14-156): 5.89e-24: 99: 17.45
+	Hs
		262201 UB2D4_HUMAN (4-164): 2.75e-74: 220: 36.03		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		262167 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		TRIM3_HUMAN (3-109): 3.92e-21: 91.3: 19.84
+	Hs
		919852 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		TRIM7_HUMAN (1-101): 4.17e-21: 91.3: 23.48
+	Hs
		749339 UB2D2_HUMAN (4-164): 5.65e-73: 217: 36.03		BRCA1_HUMAN (25-76): 3.12e-19: 86.4: 34.62