HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: NEXN (Q0ZGT2)
Nexilin (F-actin-binding protein) (Nelin)
Gene: NEXN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	34079125, 28514442, 33961781
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~I-set
Common GO terms	GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton GO:0030424 - axon
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 675
+	Hs
		1013392 ACTBL_HUMAN (2-375): 0: 735: 91.71		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		932119 ACTC_HUMAN (2-375): 0: 592: 94.12		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		915371 ACTA_HUMAN (2-375): 0: 591: 94.12		NEXN_HUMAN (1-675): 7.23e-105: 335: 100.00
+	Hs
		507933 ACTB_HUMAN (1-375): 0: 603: 100.00		FGFR1_HUMAN (349-674): 4.83e-41: 162: 13.51
+	Hs
		507942 ACTG_HUMAN (1-375): 0: 601: 98.93		FGFR1_HUMAN (349-674): 4.83e-41: 162: 13.51
+	Hs
		507943 ACTS_HUMAN (2-375): 0: 592: 93.58		FGFR1_HUMAN (349-674): 4.83e-41: 162: 13.51
+	Hs
		891771 ACTB_HUMAN (1-375): 0: 603: 100.00		MYPC3_HUMAN (10-653): 5.58e-32: 135: 11.78
+	Hs
		932159 ACTC_HUMAN (2-375): 0: 592: 94.12		MYPC3_HUMAN (10-653): 5.58e-32: 135: 11.78
+	Hs
		891928 ACTB_HUMAN (1-375): 0: 603: 100.00		PALLD_HUMAN (573-675): 5.3e-11: 68.3: 23.08
+	Mm
		250929 ACTC_MOUSE (2-375): 0: 592: 94.12		MYPC3_MOUSE (238-674): 4.61e-12: 71.8: 11.09
+	Dm
		54871 ACT6_DROME (2-375): 0: 594: 95.99		A1ZA72_DROME (357-675): 3.84e-10: 65.7: 13.08