HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 2472
+	Hs
		929856 ACTG_HUMAN (1-375): 0: 601: 98.93		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		932975 ACTS_HUMAN (2-375): 0: 592: 93.58		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Dm
		501483 ACT1_DROME (2-375): 0: 598: 98.13		SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92
+	Dm
		361136 ACT2_DROME (2-375): 0: 596: 97.59		SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92
+	Dm
		501441 ACT5_DROME (2-375): 0: 596: 95.99		SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92
+	Dm
		527089 ACT3_DROME (2-375): 0: 594: 95.46		SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92
+	Dm
		527091 ACT6_DROME (2-375): 0: 594: 95.99		SPTCA_DROME (3-2472): 1.26e-174: 598: 63.92
+	Hs
		360636 ACTS_HUMAN (2-375): 0: 592: 93.58		SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81
+	Hs
		164588 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Hs
		891697 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		929824 ACTG_HUMAN (1-375): 0: 601: 98.93		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		891706 ACTB_HUMAN (1-375): 0: 603: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		929869 ACTG_HUMAN (1-375): 0: 601: 98.93		PLEC_HUMAN (16-1253): 4.4e-31: 137: 9.18
+	Hs
		892113 ACTB_HUMAN (1-375): 0: 603: 100.00		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Hs
		506816 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB1_HUMAN (1743-2409): 3.32e-13: 78.1: 19.70
+	Hs
		892003 ACTB_HUMAN (1-375): 0: 603: 100.00		CP250_HUMAN (1768-2439): 4.39e-10: 67.7: 8.94
+	Hs
		211548 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		828573 ACTC_HUMAN (2-375): 0: 592: 94.12		CENPF_HUMAN (1723-2444): 8.12e-13: 77: 9.28
+	Hs
		211560 ACTC_HUMAN (2-375): 0: 592: 94.12		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15
+	Hs
		211561 ACTS_HUMAN (2-375): 0: 592: 93.58		ACTN4_HUMAN (1843-2219): 1.15e-09: 66.2: 20.15