HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: MILK2 (Q8IY33)
MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2)
Gene: MICALL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36307841
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~CH
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 904
+	Hs
		725637 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTN2_HUMAN (2-219): 3.17e-68: 246: 28.44
+	Hs
		211548 ACTB_HUMAN (1-375): 0: 603: 100.00		ACTN4_HUMAN (2-219): 5.5e-67: 243: 27.98
+	Hs
		506816 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB1_HUMAN (2-216): 1.41e-62: 233: 29.30
+	Hs
		211560 ACTC_HUMAN (2-375): 0: 592: 94.12		ACTN4_HUMAN (2-219): 5.5e-67: 243: 27.98
+	Hs
		211561 ACTS_HUMAN (2-375): 0: 592: 93.58		ACTN4_HUMAN (2-219): 5.5e-67: 243: 27.98
+	Hs
		891697 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTB2_HUMAN (2-219): 3.33e-61: 229: 30.28
+	Hs
		929824 ACTG_HUMAN (1-375): 0: 601: 98.93		SPTB2_HUMAN (2-219): 3.33e-61: 229: 30.28
+	Mm
		892168 ACTB_MOUSE (1-375): 0: 603: 100.00		MILK2_MOUSE (1-888): 7.2e-61: 226: 40.66
+	Hs
		932107 ACTC_HUMAN (2-375): 0: 592: 94.12		SPTB2_HUMAN (2-219): 3.33e-61: 229: 30.28
+	Mm
		929785 ACTG_MOUSE (1-375): 0: 601: 98.93		SMCA4_MOUSE (316-893): 3.57e-58: 219: 12.18
+	Dm
		361167 ACT4_DROME (2-375): 0: 589: 94.65		ACTN_DROME (1-221): 1.7e-62: 230: 25.00
+	Hs
		846910 ACTB_HUMAN (1-375): 0: 603: 100.00		SMCA4_HUMAN (316-893): 5.38e-56: 213: 12.18
+	Hs
		846917 ACTG_HUMAN (1-375): 0: 601: 98.93		SMCA4_HUMAN (316-893): 5.38e-56: 213: 12.18
+	Hs
		891976 ACTB_HUMAN (1-375): 0: 603: 100.00		CLMN_HUMAN (3-745): 1.13e-53: 204: 16.32
+	Hs
		846918 ACTC_HUMAN (2-375): 0: 592: 94.12		SMCA4_HUMAN (316-893): 5.38e-56: 213: 12.18
+	Hs
		846919 ACTS_HUMAN (2-375): 0: 592: 93.58		SMCA4_HUMAN (316-893): 5.38e-56: 213: 12.18
+	Oc
		933099 ACTS_RABIT (2-375): 0: 592: 93.58		Q07931_RABIT (2-132): 1.71e-58: 204: 40.46
+	Sp
		142705 ACT_SCHPO (1-375): 0: 592: 90.40		AIN1_SCHPO (1-116): 2.3e-50: 190: 37.61
+	Hs
		164588 ACTB_HUMAN (1-375): 0: 603: 100.00		SPTN2_HUMAN (2-106): 1.22e-21: 103: 53.33