HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: ARC1A (Q92747)
Actin-related protein 2/3 complex subunit 1A (SOP2-like protein)
Gene: ARPC1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~WD40
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 370
+	Hs
		903316 POTEE_HUMAN (1-375): 0: 736: 92.00		WDR5_HUMAN (175-363): 2.8e-38: 141: 14.87
+	Hs
		903280 ACTBL_HUMAN (2-375): 0: 735: 91.71		WDR5_HUMAN (175-363): 2.8e-38: 141: 14.87
+	Hs
		168762 ACTB_HUMAN (1-375): 0: 603: 100.00		ARC1B_HUMAN (1-369): 2.59e-83: 259: 68.10
+	Hs
		168775 ACTG_HUMAN (1-375): 0: 601: 98.93		ARC1B_HUMAN (1-369): 2.59e-83: 259: 68.10
+	Hs
		932318 ACTC_HUMAN (2-375): 0: 592: 94.12		SNR40_HUMAN (129-369): 1.6e-45: 161: 14.92
+	Hs
		891660 ACTB_HUMAN (1-375): 0: 603: 100.00		WDR5_HUMAN (175-363): 2.8e-38: 141: 14.87
+	Hs
		903110 ACTG_HUMAN (1-375): 0: 601: 98.93		WDR5_HUMAN (175-363): 2.8e-38: 141: 14.87
+	Hs
		792947 ACTB_HUMAN (1-375): 0: 603: 100.00		LIS1_HUMAN (180-365): 6.27e-34: 131: 17.19
+	Hs
		792968 ACTG_HUMAN (1-375): 0: 601: 98.93		LIS1_HUMAN (180-365): 6.27e-34: 131: 17.19
+	Sc
		863622 ACT_YEAST (1-375): 0: 591: 88.80		COPA_YEAST (3-330): 9.47e-25: 107: 10.46
+	Dm
		332994 ACT3_DROME (2-375): 0: 594: 95.46		O97182_DROME (12-236): 1.04e-10: 64.5: 13.48