HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: LIMA1 (Q9UHB6)
LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)
Gene: LIMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.709

Property	Details
Experiments	26496610, 34079125, 35235311, 34349018, 37071682
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 759
+	Hs
		1122532 ACTBL_HUMAN (2-375): 0: 735: 91.71		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		930041 ACTG_HUMAN (1-375): 0: 601: 98.93		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		932433 ACTC_HUMAN (2-375): 0: 592: 94.12		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		933070 ACTS_HUMAN (2-375): 0: 592: 93.58		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		915531 ACTA_HUMAN (2-375): 0: 591: 94.12		LIMA1_HUMAN (1-759): 0: 855: 100.00
+	Hs
		1122525 ACTBL_HUMAN (2-375): 0: 735: 91.71		LHX3_HUMAN (369-635): 7e-43: 162: 14.44
+	Hs
		891887 ACTB_HUMAN (1-375): 0: 603: 100.00		MILK2_HUMAN (295-569): 1.42e-37: 153: 22.95
+	Hs
		929877 ACTG_HUMAN (1-375): 0: 601: 98.93		CSRP2_HUMAN (254-450): 3.35e-41: 151: 18.27
+	Mm
		915552 ACTA_MOUSE (2-375): 0: 591: 94.12		LASP1_MOUSE (389-572): 7.66e-39: 146: 18.27
+	Hs
		150545 ACTB_HUMAN (1-375): 0: 603: 100.00		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		150554 ACTG_HUMAN (1-375): 0: 601: 98.93		ABLM1_HUMAN (298-548): 8.97e-23: 106: 11.28
+	Hs
		932996 ACTS_HUMAN (2-375): 0: 592: 93.58		ABLM2_HUMAN (369-647): 1.72e-22: 104: 11.79
+	Dm
		501502 ACT1_DROME (2-375): 0: 598: 98.13		MICAL_DROME (371-515): 6.96e-12: 71.8: 24.83
+	Hs
		891770 ACTB_HUMAN (1-375): 0: 603: 100.00		LASP1_HUMAN (390-480): 2.66e-11: 66.8: 25.00
+	Mm
		915554 ACTA_MOUSE (2-375): 0: 591: 94.12		PDLI5_MOUSE (310-441): 9.18e-11: 67.3: 19.55