HitPredict

Interactor 1: MSBA (P60752)
ATP-dependent lipid A-core flippase (EC 7.5.2.6) (Lipid A export ATP-binding/permease protein MsbA) (Lipid flippase)
Gene: MSBA

Interactor 2: MSBA (P60752)
ATP-dependent lipid A-core flippase (EC 7.5.2.6) (Lipid A export ATP-binding/permease protein MsbA) (Lipid flippase)
Gene: MSBA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 18024585, 25661651, 16858726
Identification Methods molecular sieving, x-ray crystallography, 3D electron microscopy, blue native page
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ABC_membrane~ABC_membrane, ABC_membrane~ABC_tran, ABC_tran~ABC_tran
Common GO terms GO:0005524 - ATP binding
GO:0005886 - plasma membrane
GO:0006869 - lipid transport
GO:0008289 - lipid binding
GO:0008559 - ABC-type xenobiotic transporter activity
and 9 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 582
Ec

1 582
+ Ec
+ Se
+ Vc
+ Hs
+ Mm
+ Ce
+ Tm
+ Rn
+ At
+ Hs
+ Sc

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Last updated: 15 Jul 2024