HitPredict

Interactor 1: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: DSC2 (Q02487)
Desmocollin-2 (Cadherin family member 2) (Desmocollin-3) (Desmosomal glycoprotein II) (Desmosomal glycoprotein III)
Gene: DSC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0031410 - cytoplasmic vesicle GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 901
+	Hs
		925210 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		545331 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		971065 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		950934 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		893916 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		DSC2_HUMAN (1-901): 0: 855: 100.00
+	Hs
		1055855 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		DSC3_HUMAN (1-901): 0: 806: 66.70
+	Hs
		521837 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		CADH1_HUMAN (28-897): 0: 714: 28.09
+	Hs
		893915 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		DSG1_HUMAN (130-573): 2.65e-65: 239: 33.18
+	Hs
		580220 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		545200 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		580261 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		580218 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		580224 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		CADH2_HUMAN (4-385): 1.04e-51: 197: 15.55
+	Hs
		925399 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		DSG4_HUMAN (20-372): 1.22e-32: 138: 17.84
+	Hs
		925270 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		545367 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		1048664 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		892364 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		950987 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18
+	Hs
		893994 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		DSG2_HUMAN (69-401): 2e-20: 99.3: 17.18