HitPredict

Interactor 1: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2471
+	Hs
		925219 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		545337 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		980532 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		950942 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		893926 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		804195 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		545253 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		804343 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		804186 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		804203 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		804187 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88
+	Hs
		925238 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		925204 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		950953 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		893947 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		925184 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42
+	Hs
		545315 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42
+	Hs
		944130 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42
+	Hs
		892313 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42
+	Hs
		944117 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		JAG1_HUMAN (1136-1552): 1.01e-29: 131: 20.42