HitPredict

Interactor 1: RAC3 (P60763)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: PHAR4 (Q8IZ21)
Phosphatase and actin regulator 4
Gene: PHACTR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0030027 - lamellipodium GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 702
+	Hs
		925424 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		545487 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		1223916 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		951142 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		894200 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		900673 RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32		PHAR4_HUMAN (1-702): 3.04e-73: 252: 100.00
+	Hs
		925215 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		DYST_HUMAN (477-699): 6.74e-36: 148: 17.83
+	Hs
		545334 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		DYST_HUMAN (477-699): 6.74e-36: 148: 17.83
+	Hs
		166043 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		SYNJ2_HUMAN (57-579): 1.23e-26: 118: 12.09
+	Hs
		166039 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		SYNJ2_HUMAN (57-579): 1.23e-26: 118: 12.09
+	Hs
		297823 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		K0754_HUMAN (100-652): 9.48e-20: 97: 10.70
+	Hs
		297812 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		K0754_HUMAN (100-652): 9.48e-20: 97: 10.70
+	Hs
		297840 RHOJ_HUMAN (2-190): 2.64e-80: 239: 60.32		K0754_HUMAN (100-652): 9.48e-20: 97: 10.70
+	Hs
		297819 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		K0754_HUMAN (100-652): 9.48e-20: 97: 10.70
+	Hs
		297827 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		K0754_HUMAN (100-652): 9.48e-20: 97: 10.70
+	Hs
		297820 RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32		K0754_HUMAN (100-652): 9.48e-20: 97: 10.70
+	Hs
		297809 RHOC_HUMAN (5-192): 2.99e-74: 223: 54.79		K0754_HUMAN (100-652): 9.48e-20: 97: 10.70
+	Ce
		136793 RAC1_CAEEL (1-192): 1.53e-82: 244: 81.25		UNC89_CAEEL (2-256): 1.9e-11: 69.9: 14.07
+	Ce
		104464 G5EBV3_CAEEL (2-192): 2.34e-77: 231: 63.87		UNC89_CAEEL (2-256): 1.9e-11: 69.9: 14.07
+	Ce
		136794 CDC42_CAEEL (1-192): 3.66e-75: 225: 67.71		UNC89_CAEEL (2-256): 1.9e-11: 69.9: 14.07