Interactor 1: DNLI4 (P49917)
DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)
Gene: LIG4
Interactor 2: XRCC4 (Q13426)
DNA repair protein XRCC4 (hXRCC4) (X-ray repair cross-complementing protein 4) [Cleaved into: Protein XRCC4, C-terminus (XRCC4/C)]
Gene: XRCC4
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.98 | 1.00 | 0.992 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26186194, 28514442, 17567543, 9259561, 9705934, 32296183, 33961781, 15520013, 10757784, 25416956, 25910212, 30496552, 11702069, 11809878, 15194694, 22658747, 21070942, 31548606, unassigned3799, 23219551 and 3 others
more... |
| Identification Methods | affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, molecular sieving, light scattering, x ray scattering, validated two hybrid, anti tag coimmunoprecipitation and 5 others
more... |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | BRCT~XRCC4_CC, DNA_ligase_IV~XRCC4_CC |
| Common GO terms | GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex GO:0006284 - base-excision repair and 7 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Last updated: 11Aug2025
