HitPredict

Interactor 1: RAC3 (P60764)
Ras-related C3 botulinum toxin substrate 3 (EC 3.6.5.2) (p21-Rac3)
Gene: RAC3

Interactor 2: GDIR2 (Q61599)
Rho GDP-dissociation inhibitor 2 (Rho GDI 2) (D4) (Rho-GDI beta)
Gene: Arhgdib

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~Rho_GDI
Common GO terms	GO:0003924 - GTPase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Mm			1 200
+	Hs
		854769 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Mm
		925816 RAC1_MOUSE (1-192): 1.92e-84: 249: 92.71		GDIR1_MOUSE (1-200): 4.25e-105: 302: 64.71
+	Hs
		545278 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Hs
		854759 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Mm
		892716 RAC3_MOUSE (1-192): 5.54e-79: 235: 100.00		GDIR1_MOUSE (1-200): 4.25e-105: 302: 64.71
+	Hs
		854771 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Hs
		854851 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		GDIR2_HUMAN (1-200): 4.41e-99: 287: 86.57
+	Hs
		854760 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Hs
		925561 RAC1_HUMAN (1-192): 1.92e-84: 249: 92.71		GDIR3_HUMAN (1-200): 1.76e-97: 283: 56.22
+	Hs
		854763 RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32		GDIR1_HUMAN (1-200): 1.83e-105: 303: 65.69
+	Rn
		901290 RHOA_RAT (5-192): 9.79e-77: 229: 54.79		GDIR1_RAT (1-200): 4.25e-105: 302: 64.71
+	Hs
		545279 RAC2_HUMAN (1-192): 6.96e-81: 240: 88.54		GDIR2_HUMAN (1-200): 4.41e-99: 287: 86.57
+	Hs
		854847 RAC3_HUMAN (1-192): 5.54e-79: 235: 100.00		GDIR2_HUMAN (1-200): 4.41e-99: 287: 86.57
+	Hs
		854852 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		GDIR2_HUMAN (1-200): 4.41e-99: 287: 86.57
+	Hs
		951270 RHOG_HUMAN (1-192): 2.62e-78: 233: 69.79		GDIR3_HUMAN (1-200): 1.76e-97: 283: 56.22
+	Hs
		894357 CDC42_HUMAN (1-192): 3.66e-77: 230: 68.75		GDIR3_HUMAN (1-200): 1.76e-97: 283: 56.22
+	Hs
		900840 RHOA_HUMAN (5-192): 2.22e-76: 228: 55.32		GDIR3_HUMAN (1-200): 1.76e-97: 283: 56.22
+	At
		1105170 RAC5_ARATH (4-177): 1.21e-78: 234: 64.37		GDIR_ARATH (1-198): 5.09e-88: 260: 38.00
+	Ce
		975573 RAC1_CAEEL (1-192): 1.53e-82: 244: 81.25		GDIR_CAEEL (12-197): 1.56e-74: 224: 39.04
+	Cl
		47354 RAC1_CANLF (1-192): 1.92e-84: 249: 92.71		A0A8I3N6C6_CANLF (1-200): 2.17e-70: 213: 47.55