HitPredict

Interactor 1: CDC42 (P60766)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: DOC10 (Q8BZN6)
Dedicator of cytokinesis protein 10 (Zizimin-3)
Gene: Dock10

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15710388
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras, PH~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043197 - dendritic spine GO:0060997 - dendritic spine morphogenesis GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Mm			1 2187
+	Hs
		894298 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DOC10_HUMAN (1-2187): 0: 3072: 93.74
+	Mm
		101404 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		F8VPN7_MOUSE (30-2187): 0: 2779: 52.37
+	Hs
		564671 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DOCK9_HUMAN (2-2149): 0: 2746: 51.38
+	Hs
		1317682 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DOCK9_HUMAN (2-2149): 0: 2746: 51.38
+	Hs
		925588 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK9_HUMAN (2-2149): 0: 2746: 51.38
+	Hs
		564557 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		DOC11_HUMAN (4-2175): 0: 2632: 49.45
+	Hs
		1127531 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		DOC11_HUMAN (4-2175): 0: 2632: 49.45
+	Hs
		925332 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOC11_HUMAN (4-2175): 0: 2632: 49.45
+	Hs
		894099 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DOC11_HUMAN (4-2175): 0: 2632: 49.45
+	Mm
		57052 CDC42_MOUSE (1-191): 4.96e-82: 243: 100.00		DOC11_MOUSE (4-2175): 0: 2606: 49.38
+	Hs
		925448 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK8_HUMAN (309-956): 0: 685: 29.49
+	Hs
		894226 CDC42_HUMAN (1-191): 4.96e-82: 243: 100.00		DOCK8_HUMAN (309-956): 0: 685: 29.49
+	Hs
		925425 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK3_HUMAN (1804-2170): 5.52e-119: 422: 22.92
+	Hs
		925486 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK2_HUMAN (1788-2183): 4.03e-112: 399: 19.90
+	Hs
		925620 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK5_HUMAN (1804-2141): 8.27e-112: 398: 21.33
+	Mm
		925807 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		DOCK1_MOUSE (672-1043): 8.25e-16: 86.4: 19.05
+	Hs
		925518 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK6_HUMAN (1-180): 3.27e-15: 84.5: 24.73
+	Hs
		925276 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK1_HUMAN (672-1036): 5.67e-15: 83.7: 19.95
+	Hs
		925429 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK4_HUMAN (421-1092): 1.91e-14: 81.8: 16.45
+	Hs
		925526 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		DOCK7_HUMAN (4-183): 1.32e-12: 76: 23.62