HitPredict

Interactor 1: CDC42 (P60766)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Interactor 2: SRGP1 (Q91Z69)
SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)
Gene: Srgap1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11672528
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0007266 - Rho protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Mm			1 1062
+	Hs
		253311 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		SRGP2_HUMAN (1-1062): 0: 606: 67.07
+	Hs
		200213 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		SRGP3_HUMAN (1-1024): 0: 590: 66.10
+	Hs
		564562 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG21_HUMAN (331-1020): 2.36e-80: 290: 17.89
+	Hs
		64652 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG32_HUMAN (423-1014): 4.63e-79: 286: 14.62
+	Hs
		245184 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		OPHN1_HUMAN (115-896): 3.62e-85: 294: 15.93
+	Hs
		63073 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG42_HUMAN (115-958): 1.73e-84: 294: 13.52
+	Hs
		1133703 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG21_HUMAN (331-1020): 2.36e-80: 290: 17.89
+	Hs
		64741 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG32_HUMAN (423-1014): 4.63e-79: 286: 14.62
+	Mm
		1194500 RHOJ_MOUSE (2-179): 1.33e-84: 250: 65.17		RHG33_MOUSE (386-1022): 2.07e-79: 286: 18.05
+	Hs
		64688 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG32_HUMAN (423-1014): 4.63e-79: 286: 14.62
+	Mm
		925803 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG32_MOUSE (423-1030): 1.49e-77: 282: 14.42
+	Hs
		147862 RAC1_HUMAN (1-191): 1.75e-84: 249: 70.31		RHG33_HUMAN (386-1024): 5.62e-77: 279: 16.84
+	Mm
		925793 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		ABR_MOUSE (25-650): 4.29e-70: 253: 15.21
+	Mm
		925802 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		CHIO_MOUSE (497-671): 1.11e-71: 243: 33.71
+	Ce
		88245 RAC1_CAEEL (1-191): 5.53e-85: 250: 65.97		D3YT54_CAEEL (490-709): 1.75e-42: 167: 45.46
+	Mm
		925805 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		RHG22_MOUSE (486-713): 2.51e-23: 108: 32.07
+	Hs
		564503 RHOQ_HUMAN (4-187): 7.35e-91: 266: 67.94		RHG05_HUMAN (496-671): 1.12e-16: 87.8: 32.77
+	Hs
		1330939 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG35_HUMAN (496-641): 1.49e-18: 94: 33.56
+	Hs
		1022689 RHOJ_HUMAN (2-188): 2.67e-85: 252: 64.17		RHG05_HUMAN (496-671): 1.12e-16: 87.8: 32.77
+	Mm
		925798 RAC1_MOUSE (1-191): 1.75e-84: 249: 70.31		BCR_MOUSE (496-650): 1.79e-17: 90.5: 32.90